Donor-Derived Long-Term Multilineage Hematopoiesis in a Liver-Transplant Recipient

Robert H. Collins, John Anastasi, Leon W M M Terstappen, Afzal Nikaein, Jiajia Feng, Joseph W. Fay, Goran Klintmalm, Marvin J. Stone

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Graft-versus-host disease (GVHD) has been well documented in several recipients of liver transplants18. In this syndrome alloreactive cells from the donor attack the recipient's skin, gastrointestinal tissue, and hematopoietic tissue. Severe myelosuppression commonly results, but there has been a degree of recovery of hematopoiesis in some patients after immunosuppressive therapy. The recovery of hematopoiesis resulted from the recovery of the recipient's bone marrow in some cases,1,3 but it also could be due to the proliferation of hematopoietic precursor cells in the donor's liver, since the liver is a site of hematopoiesis in fetuses and, under certain circumstances,…

Original languageEnglish (US)
Pages (from-to)762-765
Number of pages4
JournalNew England Journal of Medicine
Volume328
Issue number11
DOIs
StatePublished - Mar 18 1993

ASJC Scopus subject areas

  • Medicine(all)

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