Donor-recipient mismatches in MHC class I chain-related gene a in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease

Simrit Parmar, Marcos De Lima, Yizhou Zou, Poliana A. Patah, Ping Liu, Pedro Cano, Gabriela Rondon, Susana Pesoa, Leandro De Padua Silva, Muzaffar H. Qazilbash, Chitra Hosing, Uday Popat, Partow Kebriaei, Elizabeth J. Shpall, Sergio Giralt, Richard E. Champlin, Peter Stastny, Marcelo Fernandez-Vina

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

The polymorphic products of major histocompatibility complex class I-related chain A (MICA) genes are important in solid organ transplantation rejection. MICA expression is limited to gut epithelium and may play a role in triggering acute graft-versus-host disease (aGVHD). A total of 236 recipients of unrelated donor transplantation were studied. Donor-recipient human leukocyte antigen (HLA) match was 10/10 human leukocyte antigen (HLA-A, -B, -C, -DRB1, -DQB1) in 73% and MICA mismatch in 8.4%. Because of physical vicinity of the loci, MICA mismatch was significantly associated with mismatch at HLA-B and HLA-C. A higher rate of grade II-IV aGVHD was seen in MICA-mismatched patients (80% vs 40%, P = .003) irrespective of degree of HLA matching (HLA 10/10 match: 75% vs 39%, P = .02) and HLA any mismatch (83% vs 46%, P = .003). The rate of grade II-IV gastrointestinal aGVHD was also higher in MICA-mismatched patients (35% vs 17%, P = .05). We conclude that MICA may represent novel a transplantation antigen recognized by human allogeneic T cells. This study was registered at ClinicalTrials.gov (Identifier NCT00506922).

Original languageEnglish (US)
Pages (from-to)2884-2887
Number of pages4
JournalBlood
Volume114
Issue number14
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Parmar, S., De Lima, M., Zou, Y., Patah, P. A., Liu, P., Cano, P., Rondon, G., Pesoa, S., De Padua Silva, L., Qazilbash, M. H., Hosing, C., Popat, U., Kebriaei, P., Shpall, E. J., Giralt, S., Champlin, R. E., Stastny, P., & Fernandez-Vina, M. (2009). Donor-recipient mismatches in MHC class I chain-related gene a in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease. Blood, 114(14), 2884-2887. https://doi.org/10.1182/blood-2009-05-223172