Dormancy in a model of murine B cell lymphoma

Jonathan W. Uhr, Radu Marches

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

A B cell lymphoma model of dormancy in mice was established by prior immunization to the B cell membrane immunoglobulin idiotype. The antibody to the idiotype was the major factor in inducing and maintaining dormancy and acted primarily as an agonist rather than via effector functions. CD8+ T cells synergized with anti-Id in inducing dormancy by secreting IFNγ. Cycling in the dormant population was reduced 3-5 fold, but each mouse contained approximately 106 tumor cells in its spleen, some of which were cycling, during the 1.5 years of observation. Thus, replication is balanced by cell death.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalSeminars in Cancer Biology
Volume11
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Anti-idiotype
  • Immunization
  • Murine lymphoma
  • Signaling

ASJC Scopus subject areas

  • Cancer Research

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