Drugging ACAT1 for Cancer Therapy

Javier Garcia-Bermudez, Kivanç Birsoy

Research output: Contribution to journalShort surveypeer-review

10 Scopus citations

Abstract

In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of mitochondrial acetyl-coA acetyltransferase 1 (ACAT1). The authors further identify a small molecule ACAT1 inhibitor that displays anti-cancer effects.

Original languageEnglish (US)
Pages (from-to)856-857
Number of pages2
JournalMolecular cell
Volume64
Issue number5
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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