Drugging ACAT1 for Cancer Therapy

Javier Garcia-Bermudez; Kivanç Birsoy

doi:10.1016/j.molcel.2016.11.023

Drugging ACAT1 for Cancer Therapy

Javier Garcia-Bermudez, Kivanç Birsoy

Research output: Contribution to journal › Short survey › peer-review

15 Scopus citations

Abstract

In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of mitochondrial acetyl-coA acetyltransferase 1 (ACAT1). The authors further identify a small molecule ACAT1 inhibitor that displays anti-cancer effects.

Original language	English (US)
Pages (from-to)	856-857
Number of pages	2
Journal	Molecular cell
Volume	64
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2016.11.023
State	Published - Dec 1 2016
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2016.11.023

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title = "Drugging ACAT1 for Cancer Therapy",

abstract = "In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of mitochondrial acetyl-coA acetyltransferase 1 (ACAT1). The authors further identify a small molecule ACAT1 inhibitor that displays anti-cancer effects.",

author = "Javier Garcia-Bermudez and Kivan{\c c} Birsoy",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

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day = "1",

doi = "10.1016/j.molcel.2016.11.023",

language = "English (US)",

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T1 - Drugging ACAT1 for Cancer Therapy

AU - Garcia-Bermudez, Javier

AU - Birsoy, Kivanç

PY - 2016/12/1

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N2 - In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of mitochondrial acetyl-coA acetyltransferase 1 (ACAT1). The authors further identify a small molecule ACAT1 inhibitor that displays anti-cancer effects.

AB - In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of mitochondrial acetyl-coA acetyltransferase 1 (ACAT1). The authors further identify a small molecule ACAT1 inhibitor that displays anti-cancer effects.

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DO - 10.1016/j.molcel.2016.11.023

M3 - Short survey

C2 - 27912096

AN - SCOPUS:85003691570

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VL - 64

SP - 856

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JO - Molecular cell

JF - Molecular cell

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Drugging ACAT1 for Cancer Therapy

Abstract

ASJC Scopus subject areas

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