D2-type dopamine receptors in postmortem human brain sections from normal and schizophrenic subjects

Robert A. Lahti, Rosalinda C. Roberts, Robert R. Conley, Erika V. Cochrane, Alex Mutin, Carol A. Tamminga

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The density of the presumed dopamine D4 receptor ([3H]YM-09151-2 minus [3H]raclopride), as well as the densities of the two ligands themselves were compared in various areas of cerebral tissue from normal versus schizophrenic subjects off or on antipsychotic drugs at the time of death. Using autoradiographic techniques, and analyzing various brain areas, no differences were found in the density of the D4 receptor, nor were differences found between the groups, in any brain region, in the amount of bound [3H]YM-09151-2 or [3H]raclopride. There were, therefore, no differences in the density of the D2-type receptors, including the D4 receptor, in normal and schizophrenic subjects off or on antipsychotic drugs at the time of death.

Original languageEnglish (US)
Pages (from-to)1945-1948
Number of pages4
JournalNeuroReport
Volume7
Issue number12
DOIs
StatePublished - 1996

Keywords

  • D
  • D
  • D
  • [H]YM-09151-2
  • [H]racl opride
  • dopamine
  • human
  • postmortem
  • receptor
  • schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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