Dysmorphic villi mimicking partial mole in a case with del(18)(q21)

Dinesh Rakheja, Kathleen S Wilson, Beverly B. Rogers

Research output: Contribution to journalArticle

Abstract

In this article, we report the histopathologic findings in a placenta from an early second trimester abortion. The placental villi showed prominent scalloping with many intravillous trophoblastic pseudoinclusions and mild trophoblastic hyperplasia, mimicking the morphology of partial hydatidiform mole. The placental karyotype was 46,XY,del(18)(q21). These histopathologic changes have been previously described in numerical chromosomal aberrations like triploidy, tetraploidy, and trisomies, but not in structural chromosomal abnormalities.

Original languageEnglish (US)
Pages (from-to)546-548
Number of pages3
JournalPediatric and Developmental Pathology
Volume7
Issue number5
DOIs
StatePublished - Nov 2004

Fingerprint

Chromosome Aberrations
Chorionic Villi
Triploidy
Hydatidiform Mole
Tetraploidy
Trisomy
Second Pregnancy Trimester
Karyotype
Placenta
Hyperplasia

Keywords

  • Chromosomal deletion
  • Dysmorphic villi
  • Partial hydatidiform mole

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Dysmorphic villi mimicking partial mole in a case with del(18)(q21). / Rakheja, Dinesh; Wilson, Kathleen S; Rogers, Beverly B.

In: Pediatric and Developmental Pathology, Vol. 7, No. 5, 11.2004, p. 546-548.

Research output: Contribution to journalArticle

@article{0bd2b69ea9ba49e8abeb4659e0e93e46,
title = "Dysmorphic villi mimicking partial mole in a case with del(18)(q21)",
abstract = "In this article, we report the histopathologic findings in a placenta from an early second trimester abortion. The placental villi showed prominent scalloping with many intravillous trophoblastic pseudoinclusions and mild trophoblastic hyperplasia, mimicking the morphology of partial hydatidiform mole. The placental karyotype was 46,XY,del(18)(q21). These histopathologic changes have been previously described in numerical chromosomal aberrations like triploidy, tetraploidy, and trisomies, but not in structural chromosomal abnormalities.",
keywords = "Chromosomal deletion, Dysmorphic villi, Partial hydatidiform mole",
author = "Dinesh Rakheja and Wilson, {Kathleen S} and Rogers, {Beverly B.}",
year = "2004",
month = "11",
doi = "10.1007/s10024-004-2022-8",
language = "English (US)",
volume = "7",
pages = "546--548",
journal = "Pediatric and Developmental Pathology",
issn = "1093-5266",
publisher = "Society for Pediatric Pathology",
number = "5",

}

TY - JOUR

T1 - Dysmorphic villi mimicking partial mole in a case with del(18)(q21)

AU - Rakheja, Dinesh

AU - Wilson, Kathleen S

AU - Rogers, Beverly B.

PY - 2004/11

Y1 - 2004/11

N2 - In this article, we report the histopathologic findings in a placenta from an early second trimester abortion. The placental villi showed prominent scalloping with many intravillous trophoblastic pseudoinclusions and mild trophoblastic hyperplasia, mimicking the morphology of partial hydatidiform mole. The placental karyotype was 46,XY,del(18)(q21). These histopathologic changes have been previously described in numerical chromosomal aberrations like triploidy, tetraploidy, and trisomies, but not in structural chromosomal abnormalities.

AB - In this article, we report the histopathologic findings in a placenta from an early second trimester abortion. The placental villi showed prominent scalloping with many intravillous trophoblastic pseudoinclusions and mild trophoblastic hyperplasia, mimicking the morphology of partial hydatidiform mole. The placental karyotype was 46,XY,del(18)(q21). These histopathologic changes have been previously described in numerical chromosomal aberrations like triploidy, tetraploidy, and trisomies, but not in structural chromosomal abnormalities.

KW - Chromosomal deletion

KW - Dysmorphic villi

KW - Partial hydatidiform mole

UR - http://www.scopus.com/inward/record.url?scp=15244339142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15244339142&partnerID=8YFLogxK

U2 - 10.1007/s10024-004-2022-8

DO - 10.1007/s10024-004-2022-8

M3 - Article

C2 - 15547780

AN - SCOPUS:15244339142

VL - 7

SP - 546

EP - 548

JO - Pediatric and Developmental Pathology

JF - Pediatric and Developmental Pathology

SN - 1093-5266

IS - 5

ER -