Early and midterm outcomes of transcatheter aortic valve replacement in patients with bicuspid aortic valves

Seyed Hossein Aalaei-Andabili, Thomas M. Beaver, John W. Petersen, R. David Anderson, Ashkan Karimi, Eric Thoburn, Ali Kabir, Anthony A. Bavry, George J. Arnaoutakis

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1 Scopus citations

Abstract

Background: Bicuspid aortic valve (BAV) stenosis has been considered a relative contraindication to transcatheter aortic valve replacement (TAVR). We compared the outcomes of TAVR in patients with BAV stenosis versus patients with trileaflet aortic valve stenosis. Methods: From March 2012 to September 2017, 727 patients underwent TAVR. Thirty-two patients with BAV were included in this study and compared to 96 patients with comparable risk factors (1:3) with a trileaflet aortic valve (TAV). Transesophageal echocardiography was used to estimate post-TAVR degree of paravalvular leak (PVL). Results: Mean ± standard deviation Society of Thoracic Surgeons risk was 6.01 ± 3.42 in the BAV group and 6.08 ± 3.76 in the TAV group (P = 0.92). Thirty-day mortality was 4.2% (N = 4) in the TAV group and 6.25% (N = 2) in the BAV group (P = 0.63). Three (3.1%) patients in the TAV group and two (6.25%) patients in the BAV group developed a post operative stroke (P = 0.59). Following TAVR, mean aortic valve gradient significantly decreased in both TAV (42.56 ± 14.93 vs 9.27 ± 5.57, P < 0.001) and BAV (44.12 ± 11.82 vs 9.03 ± 7.29, P < 0.001) groups. No patient had a severe PVL after TAVR, and only two (2.08%) patients in the TAV group and one (3.12%) patient in the BAV group had moderate PVL (P = 1.0). Patient survival rate at 1 and 2 years was 86% in the BAV group and 90% at 1 and 2 years in the TAV group (P = 0.74). Conclusions: TAVR in BAV disease is feasible with favorable valve performance. Immediate and mid-term outcomes of TAVR in patients with BAV are comparable to those with TAV.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
JournalJournal of Cardiac Surgery
Volume33
Issue number9
DOIs
StatePublished - Sep 2018
Externally publishedYes

Keywords

  • bicuspid aortic valve
  • outcome
  • perivalvular leak
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Aalaei-Andabili, S. H., Beaver, T. M., Petersen, J. W., Anderson, R. D., Karimi, A., Thoburn, E., Kabir, A., Bavry, A. A., & Arnaoutakis, G. J. (2018). Early and midterm outcomes of transcatheter aortic valve replacement in patients with bicuspid aortic valves. Journal of Cardiac Surgery, 33(9), 489-496. https://doi.org/10.1111/jocs.13775