Early repair of congenital heart disease associated with increased rate of attention deficit hyperactivity disorder symptoms

Drew C. Yamada, Aisling A. Porter, Jennifer L. Conway, John C. LeBlanc, Sarah E. Shea, Camille L. Hancock-Friesen, Andrew E. Warren

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: As more children survive with congenital heart disease, their neurodevelopmental outcomes (including attention deficit hyperactivity disorder [ADHD]) are becoming increasingly important. The objective of our study was to determine if school-aged children who underwent early cardiac surgery for congenital heart disease are more likely than healthy control subjects to have screening scores on the Swanson, Nolan, and Pelham IV (SNAP-IV) questionnaire suggestive of ADHD. Methods: Children aged 7-15 years who underwent open-heart surgery before 1 year of age were identified from the Izaak Walton Killam (IWK) Children's Heart Centre Database. Control subjects were recruited from healthy volunteers. The SNAP-IV questionnaire was administered to all participants and a chart review was performed on all eligible children in the cardiac surgery group. Case and control subjects were compared using Fisher's exact test, linear, and logistic regression analyses. Potential predictors of a positive screening score were sought. Results: A positive screening score was found in 29% (16/56) of the surgical group compared with 3% (2/60) of the control group (P<0.001). Surgical and control subjects differed in average overall scores (0.93 vs 0.30; P < 0.001) and in scores for hyperactivity (0.83 vs 0.24; P < 0.001) and inattention (1.04 vs 0.37; P < 0.001). No other significant predictors of a positive screening score were identified. Theearly open-heart surgery participants who responded to the questionnaire did not differ in baseline characteristics compared with nonresponders. Conclusions: Children who have open-heart surgery at younger than 1 year of age are more likely than healthy control subjects to have a SNAP-IV score suggestive of ADHD when they reach school age.

Original languageEnglish (US)
Pages (from-to)1623-1628
Number of pages6
JournalCanadian Journal of Cardiology
Volume29
Issue number12
DOIs
StatePublished - Dec 1 2013

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Attention Deficit Disorder with Hyperactivity
Heart Diseases
Thoracic Surgery
Healthy Volunteers
Linear Models
Logistic Models
Regression Analysis
Databases
Control Groups
Surveys and Questionnaires

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Early repair of congenital heart disease associated with increased rate of attention deficit hyperactivity disorder symptoms. / Yamada, Drew C.; Porter, Aisling A.; Conway, Jennifer L.; LeBlanc, John C.; Shea, Sarah E.; Hancock-Friesen, Camille L.; Warren, Andrew E.

In: Canadian Journal of Cardiology, Vol. 29, No. 12, 01.12.2013, p. 1623-1628.

Research output: Contribution to journalArticle

Yamada, Drew C. ; Porter, Aisling A. ; Conway, Jennifer L. ; LeBlanc, John C. ; Shea, Sarah E. ; Hancock-Friesen, Camille L. ; Warren, Andrew E. / Early repair of congenital heart disease associated with increased rate of attention deficit hyperactivity disorder symptoms. In: Canadian Journal of Cardiology. 2013 ; Vol. 29, No. 12. pp. 1623-1628.
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abstract = "Background: As more children survive with congenital heart disease, their neurodevelopmental outcomes (including attention deficit hyperactivity disorder [ADHD]) are becoming increasingly important. The objective of our study was to determine if school-aged children who underwent early cardiac surgery for congenital heart disease are more likely than healthy control subjects to have screening scores on the Swanson, Nolan, and Pelham IV (SNAP-IV) questionnaire suggestive of ADHD. Methods: Children aged 7-15 years who underwent open-heart surgery before 1 year of age were identified from the Izaak Walton Killam (IWK) Children's Heart Centre Database. Control subjects were recruited from healthy volunteers. The SNAP-IV questionnaire was administered to all participants and a chart review was performed on all eligible children in the cardiac surgery group. Case and control subjects were compared using Fisher's exact test, linear, and logistic regression analyses. Potential predictors of a positive screening score were sought. Results: A positive screening score was found in 29{\%} (16/56) of the surgical group compared with 3{\%} (2/60) of the control group (P<0.001). Surgical and control subjects differed in average overall scores (0.93 vs 0.30; P < 0.001) and in scores for hyperactivity (0.83 vs 0.24; P < 0.001) and inattention (1.04 vs 0.37; P < 0.001). No other significant predictors of a positive screening score were identified. Theearly open-heart surgery participants who responded to the questionnaire did not differ in baseline characteristics compared with nonresponders. Conclusions: Children who have open-heart surgery at younger than 1 year of age are more likely than healthy control subjects to have a SNAP-IV score suggestive of ADHD when they reach school age.",
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AB - Background: As more children survive with congenital heart disease, their neurodevelopmental outcomes (including attention deficit hyperactivity disorder [ADHD]) are becoming increasingly important. The objective of our study was to determine if school-aged children who underwent early cardiac surgery for congenital heart disease are more likely than healthy control subjects to have screening scores on the Swanson, Nolan, and Pelham IV (SNAP-IV) questionnaire suggestive of ADHD. Methods: Children aged 7-15 years who underwent open-heart surgery before 1 year of age were identified from the Izaak Walton Killam (IWK) Children's Heart Centre Database. Control subjects were recruited from healthy volunteers. The SNAP-IV questionnaire was administered to all participants and a chart review was performed on all eligible children in the cardiac surgery group. Case and control subjects were compared using Fisher's exact test, linear, and logistic regression analyses. Potential predictors of a positive screening score were sought. Results: A positive screening score was found in 29% (16/56) of the surgical group compared with 3% (2/60) of the control group (P<0.001). Surgical and control subjects differed in average overall scores (0.93 vs 0.30; P < 0.001) and in scores for hyperactivity (0.83 vs 0.24; P < 0.001) and inattention (1.04 vs 0.37; P < 0.001). No other significant predictors of a positive screening score were identified. Theearly open-heart surgery participants who responded to the questionnaire did not differ in baseline characteristics compared with nonresponders. Conclusions: Children who have open-heart surgery at younger than 1 year of age are more likely than healthy control subjects to have a SNAP-IV score suggestive of ADHD when they reach school age.

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