EEG-triggered echo-planar functional MRI in epilepsy

S. Warach, J. R. Ives, G. Schlaug, M. R. Patel, D. G. Darby, V. Thangaraj, R. R. Edelman, D. L. Schomer

Research output: Contribution to journalArticlepeer-review

223 Scopus citations


We investigated whether: (1) EEG recordings could be successfully performed in an MRI imager, (2) subclinical epileptic discharges could be used to trigger ultrafast functional MRI images, (3) artifact-free functional MRI images could be obtained while the patient was having the EEG monitored, and (4) the functional MRI images so obtained would show focal signal increases in relation to epileptic discharges. We report our results in two patients who showed focally higher signal intensity, reflective of increased local blood flow, in ultrafast functional MRI timed to epileptic discharges recorded while the patients were in the imager and compared with images not associated with discharges. One patient showed a focal increase despite a clinical and EEG history of generalized discharges. This approach may have the potential to identify brain regions activated during brief focal epileptic discharges.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
Issue number1
StatePublished - Jul 1996

ASJC Scopus subject areas

  • Clinical Neurology


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