Effect of anterior pituitary perfusion and intraventricular injection of catecholamines on prolactin release

I. A. Kamberi, R. S. Mical, J. C. Porter

Research output: Contribution to journalArticlepeer-review

186 Scopus citations

Abstract

In rats, the median eminence, pituitary stalk and anterior pituitary were exposed parapharyngeally and catecholamines were injected into the third ventricle or infused into a stalk portal vessel, peduncular artery, or a tuberalis ramus of an infundibular artery. Ten min after 1.25 μg dopamine hydrochloride was injected into the third ventricle, the plasma prolactin concentration was 70% of the preinjection value; 47% at 20 min; 42% at 30 min; 57% at 60 min; 69% at 90 min; and 93% at 120 min. Similar responses occurred following the administration of 2.5 μg dopamine. Quantities of dopamine greater than 2.5 jug caused less inhibition of release, however. Intraventricular injection of 2.5 or 5 μg of epinephrine or norepinephrine bitartrate did not affect prolactin release although 100 μg did. Dopamine, epinephrine, or norepinephrine, perfused into the anterior pituitary for 30 min via a hypophysial portal vein, had no effect on prolactin release. Dopamine, infused into the stalk-median eminence complex via the peduncular artery or a tuberalis ramus of an infundibular artery, had no effect on plasma prolactin levels. These findings indicate that neither dopamine, epinephrine, nor norepinephrine affected prolactin release by a direct action on the anterior pituitary but indirectly through the hypothalamic-hypophysial complex.

Original languageEnglish (US)
Pages (from-to)1012-1020
Number of pages9
JournalEndocrinology
Volume88
Issue number4
DOIs
StatePublished - Apr 1971

ASJC Scopus subject areas

  • Endocrinology

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