Effect of apomorphine on schizophrenic symptoms

R. C. Smith, C. Tamminga, J. M. Davis

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

The effects of apomorphine on psychotic symptoms were evaluated in chronic schizophrenic patients using double-blind placebo controlled procedures. Although on the basis of dopamine theory of schizophrenia, apomorphine was expected to increase schizophrenic symptoms, in this study apomorphine substantially reduced psychotic symptoms in some chronic schizophrenic patients. No patient showed the substantial increase in psychotic symptoms previously demonstrated after the administration of IV methylphenidate. These clinical effects of apomorphine in schizophrenia may be relevant to recent pharmacological research which has indicated that apomorphine also has potent effects on presynaptic dopamine neurons, in addition to its previously described postsynaptic receptor stimulation.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalJournal of Neural Transmission
Volume40
Issue number2
DOIs
StatePublished - Jun 1 1977

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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