Effect of artificial surfactant on pulmonary function in preterm and full-term lambs

I. M. Gladstone, A. O. Ray, C. M. Salafia, J. Perez-Fontan, M. R. Mercurio, H. C. Jacobs

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We hypothesized that agents very different from surfactant may still support lung function. To test this hypothesis, we instilled FC-100, a fluorocarbon, and Tween 20, a detergent, which have higher minimum surface tensions and less hysteresis than surfactant, into 15 full-term and 14 preterm lambs. FC-100 and Tween 20 were as efficient as natural surfactant in improving gas exchange and compliance in preterm lambs with respiratory failure. Dynamic compliance correlated with the equilibrium surface tension of the alveolar wash in both full-term (P < 0.02) and preterm (P < 0.008) lambs. Functional residual capacity in full-term and preterm lambs was lower after treatment with the two test agents than with surfactant, findings consistent with qualitative histology. Oxygenation in full-term lambs correlated with mean lung volumes (P < 0.003), suggesting that the hysteresis and/or low minimum surface tension of surfactant may improve mean lung volume, and hence oxygenation, by maintaining functional residual capacity. The effects of the test agents suggest that agents with biophysical properties different from surfactant may still aid lung expansion.

Original languageEnglish (US)
Pages (from-to)465-472
Number of pages8
JournalJournal of Applied Physiology
Volume69
Issue number2
StatePublished - 1990

Fingerprint

Pulmonary Surfactants
Surface-Active Agents
Surface Tension
Functional Residual Capacity
Lung
Polysorbates
Compliance
Fluorocarbons
Respiratory Insufficiency
Detergents
Histology
Gases

Keywords

  • fluorocarbon
  • mechanical ventilation
  • respiratory distress syndrome
  • surfactant replacement

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Gladstone, I. M., Ray, A. O., Salafia, C. M., Perez-Fontan, J., Mercurio, M. R., & Jacobs, H. C. (1990). Effect of artificial surfactant on pulmonary function in preterm and full-term lambs. Journal of Applied Physiology, 69(2), 465-472.

Effect of artificial surfactant on pulmonary function in preterm and full-term lambs. / Gladstone, I. M.; Ray, A. O.; Salafia, C. M.; Perez-Fontan, J.; Mercurio, M. R.; Jacobs, H. C.

In: Journal of Applied Physiology, Vol. 69, No. 2, 1990, p. 465-472.

Research output: Contribution to journalArticle

Gladstone, IM, Ray, AO, Salafia, CM, Perez-Fontan, J, Mercurio, MR & Jacobs, HC 1990, 'Effect of artificial surfactant on pulmonary function in preterm and full-term lambs', Journal of Applied Physiology, vol. 69, no. 2, pp. 465-472.
Gladstone, I. M. ; Ray, A. O. ; Salafia, C. M. ; Perez-Fontan, J. ; Mercurio, M. R. ; Jacobs, H. C. / Effect of artificial surfactant on pulmonary function in preterm and full-term lambs. In: Journal of Applied Physiology. 1990 ; Vol. 69, No. 2. pp. 465-472.
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