Effect of diabetes mellitus on the material properties of the distal tibia

John G. Fleischli, Terese J. Laughlin, Kyriacos Athanasiou, Dan R. Lanctot, Lawrence Lavery, Xiaodu Wang, C. Mauli Agrawal

Research output: Contribution to journalArticle

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Abstract

This investigation evaluates the effects of diabetes on the mechanical properties of human bone, specifically, the tibia. Seven diabetic and seven nondiabetic human (male) cadaveric distal tibiae were used in this study. The average age of the diabetic cadaveric samples was 51 years (range, 46-61 years), and the average age of the nondiabetic cadaveric samples was 75 years (range, 67-85 years). Three-point bending tests for strength and stiffness were performed on a small sample of each distal tibia. Each specimen was loaded at a constant rate until failure. From the recorded curve of load versus displacement, the ultimate and yield strength of bone and the bending modulus of bone were calculated. The diabetic samples were generally weaker than the older, nondiabetic samples, but no statistically significant differences were found in the elastic modulus (P = .29), yield strength (P = .90), ultimate strength (P = .46), and fracture toughness (P = .78), leading to speculation that diabetes has an effect similar to that of aging on the musculoskeletal system.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalJournal of the American Podiatric Medical Association
Volume96
Issue number2
StatePublished - Mar 2006

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Tibia
Diabetes Mellitus
Bone and Bones
Musculoskeletal System
Elastic Modulus

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Fleischli, J. G., Laughlin, T. J., Athanasiou, K., Lanctot, D. R., Lavery, L., Wang, X., & Agrawal, C. M. (2006). Effect of diabetes mellitus on the material properties of the distal tibia. Journal of the American Podiatric Medical Association, 96(2), 91-95.

Effect of diabetes mellitus on the material properties of the distal tibia. / Fleischli, John G.; Laughlin, Terese J.; Athanasiou, Kyriacos; Lanctot, Dan R.; Lavery, Lawrence; Wang, Xiaodu; Agrawal, C. Mauli.

In: Journal of the American Podiatric Medical Association, Vol. 96, No. 2, 03.2006, p. 91-95.

Research output: Contribution to journalArticle

Fleischli, JG, Laughlin, TJ, Athanasiou, K, Lanctot, DR, Lavery, L, Wang, X & Agrawal, CM 2006, 'Effect of diabetes mellitus on the material properties of the distal tibia', Journal of the American Podiatric Medical Association, vol. 96, no. 2, pp. 91-95.
Fleischli JG, Laughlin TJ, Athanasiou K, Lanctot DR, Lavery L, Wang X et al. Effect of diabetes mellitus on the material properties of the distal tibia. Journal of the American Podiatric Medical Association. 2006 Mar;96(2):91-95.
Fleischli, John G. ; Laughlin, Terese J. ; Athanasiou, Kyriacos ; Lanctot, Dan R. ; Lavery, Lawrence ; Wang, Xiaodu ; Agrawal, C. Mauli. / Effect of diabetes mellitus on the material properties of the distal tibia. In: Journal of the American Podiatric Medical Association. 2006 ; Vol. 96, No. 2. pp. 91-95.
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