Vliianie lipoksigenaznykh proizvodnykh linolievoi kisloty na funktsional'nuiu aktivnost' neitrofilov.

Translated title of the contribution: Effect of lipoxygenase derivatives of linoleic acid on functional activity of neutrophils

V. M. Brovkovich, A. A. Moibenko, I. A. Butovich, S. D. Brovkovich, S. A. Ogii

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of lipoxygenase derivatives of 13-hydroperoxylinoleic acid (13-HPODE) and 13-hydroxylinoleic acid (13-HODE) on zymosan-induced chemiluminescence of rat neutrophils in vitro was evaluated. It was found that both derivatives inhibit functional activity of neutrophils. The extent of inhibition was changed by preincubation of neutrophils with arachidonic or linoleic acid. On the other hand, in experiments with dogs it was shown that the extent of such inhibition considerably increases after ischemia and reperfusion of myocardium. Thus we assume that the ratio of lipoxygenase derivatives of arachidonic and linoleic acid play the regulative role in functional activity of neutrophils. It was concluded, that lipoxygenase derivatives of linoleic acid inhibited the neutrophils functional activity.

Original languageUndefined
Pages (from-to)79-84
Number of pages6
JournalUkrainskii biokhimicheskii zhurnal
Volume68
Issue number3
StatePublished - May 1996

Fingerprint

Lipoxygenase
Linoleic Acid
Neutrophils
Derivatives
Arachidonic Acid
Zymosan
Chemiluminescence
Rats
Luminescence
Reperfusion
Myocardium
Ischemia
Dogs
Experiments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Vliianie lipoksigenaznykh proizvodnykh linolievoi kisloty na funktsional'nuiu aktivnost' neitrofilov. / Brovkovich, V. M.; Moibenko, A. A.; Butovich, I. A.; Brovkovich, S. D.; Ogii, S. A.

In: Ukrainskii biokhimicheskii zhurnal, Vol. 68, No. 3, 05.1996, p. 79-84.

Research output: Contribution to journalArticle

Brovkovich, V. M. ; Moibenko, A. A. ; Butovich, I. A. ; Brovkovich, S. D. ; Ogii, S. A. / Vliianie lipoksigenaznykh proizvodnykh linolievoi kisloty na funktsional'nuiu aktivnost' neitrofilov. In: Ukrainskii biokhimicheskii zhurnal. 1996 ; Vol. 68, No. 3. pp. 79-84.
@article{f6a38b3f74624f7cae3140598941ffc3,
title = "Vliianie lipoksigenaznykh proizvodnykh linolievoi kisloty na funktsional'nuiu aktivnost' neitrofilov.",
abstract = "The effect of lipoxygenase derivatives of 13-hydroperoxylinoleic acid (13-HPODE) and 13-hydroxylinoleic acid (13-HODE) on zymosan-induced chemiluminescence of rat neutrophils in vitro was evaluated. It was found that both derivatives inhibit functional activity of neutrophils. The extent of inhibition was changed by preincubation of neutrophils with arachidonic or linoleic acid. On the other hand, in experiments with dogs it was shown that the extent of such inhibition considerably increases after ischemia and reperfusion of myocardium. Thus we assume that the ratio of lipoxygenase derivatives of arachidonic and linoleic acid play the regulative role in functional activity of neutrophils. It was concluded, that lipoxygenase derivatives of linoleic acid inhibited the neutrophils functional activity.",
author = "Brovkovich, {V. M.} and Moibenko, {A. A.} and Butovich, {I. A.} and Brovkovich, {S. D.} and Ogii, {S. A.}",
year = "1996",
month = "5",
language = "Undefined",
volume = "68",
pages = "79--84",
journal = "Ukrainian biochemical journal",
issn = "2409-4943",
publisher = "Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine (NASU)",
number = "3",

}

TY - JOUR

T1 - Vliianie lipoksigenaznykh proizvodnykh linolievoi kisloty na funktsional'nuiu aktivnost' neitrofilov.

AU - Brovkovich, V. M.

AU - Moibenko, A. A.

AU - Butovich, I. A.

AU - Brovkovich, S. D.

AU - Ogii, S. A.

PY - 1996/5

Y1 - 1996/5

N2 - The effect of lipoxygenase derivatives of 13-hydroperoxylinoleic acid (13-HPODE) and 13-hydroxylinoleic acid (13-HODE) on zymosan-induced chemiluminescence of rat neutrophils in vitro was evaluated. It was found that both derivatives inhibit functional activity of neutrophils. The extent of inhibition was changed by preincubation of neutrophils with arachidonic or linoleic acid. On the other hand, in experiments with dogs it was shown that the extent of such inhibition considerably increases after ischemia and reperfusion of myocardium. Thus we assume that the ratio of lipoxygenase derivatives of arachidonic and linoleic acid play the regulative role in functional activity of neutrophils. It was concluded, that lipoxygenase derivatives of linoleic acid inhibited the neutrophils functional activity.

AB - The effect of lipoxygenase derivatives of 13-hydroperoxylinoleic acid (13-HPODE) and 13-hydroxylinoleic acid (13-HODE) on zymosan-induced chemiluminescence of rat neutrophils in vitro was evaluated. It was found that both derivatives inhibit functional activity of neutrophils. The extent of inhibition was changed by preincubation of neutrophils with arachidonic or linoleic acid. On the other hand, in experiments with dogs it was shown that the extent of such inhibition considerably increases after ischemia and reperfusion of myocardium. Thus we assume that the ratio of lipoxygenase derivatives of arachidonic and linoleic acid play the regulative role in functional activity of neutrophils. It was concluded, that lipoxygenase derivatives of linoleic acid inhibited the neutrophils functional activity.

UR - http://www.scopus.com/inward/record.url?scp=0030132632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030132632&partnerID=8YFLogxK

M3 - Article

C2 - 9273733

AN - SCOPUS:0030132632

VL - 68

SP - 79

EP - 84

JO - Ukrainian biochemical journal

JF - Ukrainian biochemical journal

SN - 2409-4943

IS - 3

ER -