Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia

B. Eggleston, M. Patience, S. Edwards, T. Adamkiewicz, G. R. Buchanan, S. C. Davies, R. Dickerhoff, S. Donfield, S. A. Feig, R. H. Giller, A. Haight, J. Horan, L. L. Hsu, N. Kamani, P. Lane, J. E. Levine, D. Margolis, T. B. Moore, K. Ohene-Frempong, R. Redding-LallingerI. A G Roberts, Z. R. Rogers, J. E. Sanders, J. P. Scott, B. Sleight, A. A. Thompson, K. M. Sullivan, M. C. Walters

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.

Original languageEnglish (US)
Pages (from-to)673-676
Number of pages4
JournalBritish Journal of Haematology
Volume136
Issue number4
DOIs
StatePublished - Feb 2007

Keywords

  • Sickle cell anaemia
  • Transplantation

ASJC Scopus subject areas

  • Hematology

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    Eggleston, B., Patience, M., Edwards, S., Adamkiewicz, T., Buchanan, G. R., Davies, S. C., Dickerhoff, R., Donfield, S., Feig, S. A., Giller, R. H., Haight, A., Horan, J., Hsu, L. L., Kamani, N., Lane, P., Levine, J. E., Margolis, D., Moore, T. B., Ohene-Frempong, K., ... Walters, M. C. (2007). Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. British Journal of Haematology, 136(4), 673-676. https://doi.org/10.1111/j.1365-2141.2006.06486.x