Abstract
Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 673-676 |
| Number of pages | 4 |
| Journal | British Journal of Haematology |
| Volume | 136 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 2007 |
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Keywords
- Sickle cell anaemia
- Transplantation
ASJC Scopus subject areas
- Hematology
Cite this
Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia : Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. / Eggleston, B.; Patience, M.; Edwards, S.; Adamkiewicz, T.; Buchanan, G. R.; Davies, S. C.; Dickerhoff, R.; Donfield, S.; Feig, S. A.; Giller, R. H.; Haight, A.; Horan, J.; Hsu, L. L.; Kamani, N.; Lane, P.; Levine, J. E.; Margolis, D.; Moore, T. B.; Ohene-Frempong, K.; Redding-Lallinger, R.; Roberts, I. A G; Rogers, Z. R.; Sanders, J. E.; Scott, J. P.; Sleight, B.; Thompson, A. A.; Sullivan, K. M.; Walters, M. C.
In: British Journal of Haematology, Vol. 136, No. 4, 02.2007, p. 673-676.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia
T2 - Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia
AU - Eggleston, B.
AU - Patience, M.
AU - Edwards, S.
AU - Adamkiewicz, T.
AU - Buchanan, G. R.
AU - Davies, S. C.
AU - Dickerhoff, R.
AU - Donfield, S.
AU - Feig, S. A.
AU - Giller, R. H.
AU - Haight, A.
AU - Horan, J.
AU - Hsu, L. L.
AU - Kamani, N.
AU - Lane, P.
AU - Levine, J. E.
AU - Margolis, D.
AU - Moore, T. B.
AU - Ohene-Frempong, K.
AU - Redding-Lallinger, R.
AU - Roberts, I. A G
AU - Rogers, Z. R.
AU - Sanders, J. E.
AU - Scott, J. P.
AU - Sleight, B.
AU - Thompson, A. A.
AU - Sullivan, K. M.
AU - Walters, M. C.
PY - 2007/2
Y1 - 2007/2
N2 - Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.
AB - Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.
KW - Sickle cell anaemia
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=33846438578&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846438578&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.2006.06486.x
DO - 10.1111/j.1365-2141.2006.06486.x
M3 - Article
C2 - 17223910
AN - SCOPUS:33846438578
VL - 136
SP - 673
EP - 676
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 4
ER -