Effect of neuroleptic withdrawal on plasma prolactin: A possible marker of receptor adaptation

Brian Kirkpatrick, Robert W. Buchanan, Kiyoshi Maeda, William T. Carpenter, Diana Jauch, Carol A. Tamminga

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days. This rebound effect may be related to dopaminergic receptor changes in the tuberoinfundibular system that are induced by chronic neuroleptic administration.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalBiological Psychiatry
Volume26
Issue number2
DOIs
StatePublished - 1989

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Prolactin
Antipsychotic Agents
Pharmaceutical Preparations
Outpatients

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Effect of neuroleptic withdrawal on plasma prolactin : A possible marker of receptor adaptation. / Kirkpatrick, Brian; Buchanan, Robert W.; Maeda, Kiyoshi; Carpenter, William T.; Jauch, Diana; Tamminga, Carol A.

In: Biological Psychiatry, Vol. 26, No. 2, 1989, p. 131-138.

Research output: Contribution to journalArticle

Kirkpatrick, Brian ; Buchanan, Robert W. ; Maeda, Kiyoshi ; Carpenter, William T. ; Jauch, Diana ; Tamminga, Carol A. / Effect of neuroleptic withdrawal on plasma prolactin : A possible marker of receptor adaptation. In: Biological Psychiatry. 1989 ; Vol. 26, No. 2. pp. 131-138.
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