Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients: Implications for intermittent therapeutic strategies

Pablo Tebas, Keith Henry, Kristin Mondy, Steven Deeks, Herman Valdez, Cal Cohen, William G. Powderly

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

This study evaluates the change in CD4+ T cell counts among patients who achieved complete viral suppression and subsequently discontinued highly active antiretroviral therapy (HAART). We included 72 human immunodeficiency virus (HIV)-1-infected patients with plasma HIV RNA loads of <500 copies/mL for at least 3 months who then discontinued therapy for at least 12 weeks. The median CD4+ T decay while off HAART was 16 cells/mm3/month (interquartile range, -6 to -34 cells/month). The mean follow-up after therapy ended was 45 weeks. The slope of the CD4+ T cell decay was inversely correlated with the increase of CD4+ T cells while receiving HAART, baseline virus load, CD4+ T cell count at the time therapy was discontinued, age, and duration HIV RNA levels were undetectable. In a multiple regression analysis model, the increase of CD4+ T cells while receiving therapy and age were independently associated with the rate of CD4+ T cell loss.

Original languageEnglish (US)
Pages (from-to)851-854
Number of pages4
JournalJournal of Infectious Diseases
Volume186
Issue number6
DOIs
StatePublished - Sep 15 2002

Fingerprint

HIV
T-Lymphocytes
Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
Therapeutics
RNA
HIV-1
Regression Analysis
Viruses

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients : Implications for intermittent therapeutic strategies. / Tebas, Pablo; Henry, Keith; Mondy, Kristin; Deeks, Steven; Valdez, Herman; Cohen, Cal; Powderly, William G.

In: Journal of Infectious Diseases, Vol. 186, No. 6, 15.09.2002, p. 851-854.

Research output: Contribution to journalArticle

Tebas, Pablo ; Henry, Keith ; Mondy, Kristin ; Deeks, Steven ; Valdez, Herman ; Cohen, Cal ; Powderly, William G. / Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients : Implications for intermittent therapeutic strategies. In: Journal of Infectious Diseases. 2002 ; Vol. 186, No. 6. pp. 851-854.
@article{c90bf46b360648928a741468d8d97931,
title = "Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients: Implications for intermittent therapeutic strategies",
abstract = "This study evaluates the change in CD4+ T cell counts among patients who achieved complete viral suppression and subsequently discontinued highly active antiretroviral therapy (HAART). We included 72 human immunodeficiency virus (HIV)-1-infected patients with plasma HIV RNA loads of <500 copies/mL for at least 3 months who then discontinued therapy for at least 12 weeks. The median CD4+ T decay while off HAART was 16 cells/mm3/month (interquartile range, -6 to -34 cells/month). The mean follow-up after therapy ended was 45 weeks. The slope of the CD4+ T cell decay was inversely correlated with the increase of CD4+ T cells while receiving HAART, baseline virus load, CD4+ T cell count at the time therapy was discontinued, age, and duration HIV RNA levels were undetectable. In a multiple regression analysis model, the increase of CD4+ T cells while receiving therapy and age were independently associated with the rate of CD4+ T cell loss.",
author = "Pablo Tebas and Keith Henry and Kristin Mondy and Steven Deeks and Herman Valdez and Cal Cohen and Powderly, {William G.}",
year = "2002",
month = "9",
day = "15",
doi = "10.1086/342603",
language = "English (US)",
volume = "186",
pages = "851--854",
journal = "The Journal of infectious diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients

T2 - Implications for intermittent therapeutic strategies

AU - Tebas, Pablo

AU - Henry, Keith

AU - Mondy, Kristin

AU - Deeks, Steven

AU - Valdez, Herman

AU - Cohen, Cal

AU - Powderly, William G.

PY - 2002/9/15

Y1 - 2002/9/15

N2 - This study evaluates the change in CD4+ T cell counts among patients who achieved complete viral suppression and subsequently discontinued highly active antiretroviral therapy (HAART). We included 72 human immunodeficiency virus (HIV)-1-infected patients with plasma HIV RNA loads of <500 copies/mL for at least 3 months who then discontinued therapy for at least 12 weeks. The median CD4+ T decay while off HAART was 16 cells/mm3/month (interquartile range, -6 to -34 cells/month). The mean follow-up after therapy ended was 45 weeks. The slope of the CD4+ T cell decay was inversely correlated with the increase of CD4+ T cells while receiving HAART, baseline virus load, CD4+ T cell count at the time therapy was discontinued, age, and duration HIV RNA levels were undetectable. In a multiple regression analysis model, the increase of CD4+ T cells while receiving therapy and age were independently associated with the rate of CD4+ T cell loss.

AB - This study evaluates the change in CD4+ T cell counts among patients who achieved complete viral suppression and subsequently discontinued highly active antiretroviral therapy (HAART). We included 72 human immunodeficiency virus (HIV)-1-infected patients with plasma HIV RNA loads of <500 copies/mL for at least 3 months who then discontinued therapy for at least 12 weeks. The median CD4+ T decay while off HAART was 16 cells/mm3/month (interquartile range, -6 to -34 cells/month). The mean follow-up after therapy ended was 45 weeks. The slope of the CD4+ T cell decay was inversely correlated with the increase of CD4+ T cells while receiving HAART, baseline virus load, CD4+ T cell count at the time therapy was discontinued, age, and duration HIV RNA levels were undetectable. In a multiple regression analysis model, the increase of CD4+ T cells while receiving therapy and age were independently associated with the rate of CD4+ T cell loss.

UR - http://www.scopus.com/inward/record.url?scp=0037105728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037105728&partnerID=8YFLogxK

U2 - 10.1086/342603

DO - 10.1086/342603

M3 - Article

C2 - 12198623

AN - SCOPUS:0037105728

VL - 186

SP - 851

EP - 854

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

SN - 0022-1899

IS - 6

ER -