Effect of quercetin on the acyclovir intestinal absorption

Zhao gang Yang, Huan Meng, Xuan Zhang, Xiao dan Li, Wan liang Lv, Qiang Zhang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVE: To study the effect of quercetin on acyclovir intestinal absorption. METHODS: The everted gut sac and in vitro intestinal absorption tests were performed. The acyclovir transport quantity was determined by HPLC method. RESULTS: The everted gut sac study showed that quercetin significantly inhibited the function of intestinal P-glycoprotein P-gp . The acyclovir transport quantities from mucosa to serosa space, which incubated with 5, 10, 80 mg/L quercetin solution or 10 mg/L verapamil solution, were increased 0.3, 0.6, 1.0 and 1.0-fold higher than acyclovir alone, respectively. The transport quantity caused by inhibition of intestinal P-gp function fitted with Boltzmann equation. The in vitro intestinal absorption test indicated that the transported acyclovir from serosa to mucosa, incubated with 2, 5, 10 mg/L quercetin solution, was significantly decreased compared with acyclovir alone. CONCLUSION: Quercetin can enhance acyclovir intestinal absorption by inhibiting the function of P-gp.

Original languageEnglish (US)
Pages (from-to)309-312
Number of pages4
JournalBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Volume36
Issue number3
StatePublished - Jun 18 2004
Externally publishedYes

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Acyclovir
Quercetin
Intestinal Absorption
Serous Membrane
Mucous Membrane
P-Glycoprotein
Verapamil
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of quercetin on the acyclovir intestinal absorption. / Yang, Zhao gang; Meng, Huan; Zhang, Xuan; Li, Xiao dan; Lv, Wan liang; Zhang, Qiang.

In: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, Vol. 36, No. 3, 18.06.2004, p. 309-312.

Research output: Contribution to journalArticle

Yang, Zhao gang ; Meng, Huan ; Zhang, Xuan ; Li, Xiao dan ; Lv, Wan liang ; Zhang, Qiang. / Effect of quercetin on the acyclovir intestinal absorption. In: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2004 ; Vol. 36, No. 3. pp. 309-312.
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