Using finite element analysis, we examined tne diffusive uptake of carbon monoxide (DLco) in a hypothetical model consisting of a longitudinal cross section (1 nm thick) through a 100 (Jrn length pulmonary capillary of defined dimensions containing arbitrary numbers of equally spaced red blood cells (RBC). Cells are either disc-shaped or parachute-shaped with a constant perimeter length. Details of the model and computation have been published previously (Hsia et al, J. Appl. Physiol. 79(3): 1039-1047, 1995). Results show thai shape distortion of RBC as might occur under high flow conditions in the pulmonary capillary bed significantly impairs diffusive gas uptake and the magnitude of this effect varies with RBC spacing. Supported by NHLBI HL40070, l HL45716, HL46185 and 0 the American Heart Association.
|Original language||English (US)|
|State||Published - 1996|
ASJC Scopus subject areas
- Molecular Biology