Effect of the 2010 task force criteria on reclassification of cardiovascular magnetic resonance criteria for arrhythmogenic right ventricular cardiomyopathy

Ting Liu, Amit Pursnani, Umesh C. Sharma, Yongkasem Vorasettakarnkij, Daniel Verdini, Peerawut Deeprasertkul, Ashley M. Lee, Heidi Lumish, Manavjot S. Sidhu, Hector Medina, Stephan Danik, Suhny Abbara, Godtfred Holmvang, Udo Hoffmann, Brian B. Ghoshhajra

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Background: We sought to evaluate the effect of application of the revised 2010 Task Force Criteria (TFC) on the prevalence of major and minor Cardiovascular Magnetic Resonance (CMR) criteria for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) versus application of the original 1994 TFC. We also assessed the utility of MRI to identify alternative diagnoses for patients referred for ARVC evaluation. Methods. 968 consecutive patients referred to our institution for CMR with clinical suspicion of ARVC from 1995 to 2010, were evaluated for the presence of major and minor CMR criteria per the 1994 and 2010 ARVC TFC. CMR criteria included right ventricle (RV) dilatation, reduced RV ejection fraction, RV aneurysm, or regional RV wall motion abnormalities. When quantitative measures of RV size and function were not available, and in whom abnormal size or function was reported, a repeat quantitative analysis by 2 qualified CMR physicians in consensus. Results: Of 968 patients, 220 (22.7%) fulfilled either a major or a minor 1994 TFC, and 25 (2.6%) fulfilled any of the 2010 TFC criterion. Among patients meeting any 1994 criteria, only 25 (11.4%) met at least one 2010 criterion. All patients who fulfilled a 2010 criteria also satisfied at least one 1994 criterion. Per the 2010 TFC, 21 (2.2%) patients met major criteria and 4 (0.4%) patients fulfilled at least one minor criterion. Eight patients meeting 1994 minor criteria were reclassified as satisfying 2010 major criteria, while 4 patients fulfilling 1994 major criteria were reclassified to only minor or no criteria under the 2010 TFC.Eighty-nine (9.2%) patients had alternative cardiac diagnoses, including 43 (4.4%) with clinically significant potential ARVC mimics. These included cardiac sarcoidosis, RV volume overload conditions, and other cardiomyopathies. Conclusions: Application of the 2010 TFC resulted in reduction of total patients meeting any diagnostic CMR criteria for ARVC from 22.7% to 2.6% versus the 1994 TFC. CMR identified alternative cardiac diagnoses in 9.2% of patients, and 4.4% of the diagnoses were potential mimics of ARVC.

Original languageEnglish (US)
Article number47
JournalJournal of Cardiovascular Magnetic Resonance
Volume16
Issue number1
DOIs
StatePublished - Jul 4 2014

Keywords

  • 2010 task force criteria
  • Arrhythmogenic right ventricular cardiomyopathy
  • Cardiovascular magnetic resonance

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Liu, T., Pursnani, A., Sharma, U. C., Vorasettakarnkij, Y., Verdini, D., Deeprasertkul, P., Lee, A. M., Lumish, H., Sidhu, M. S., Medina, H., Danik, S., Abbara, S., Holmvang, G., Hoffmann, U., & Ghoshhajra, B. B. (2014). Effect of the 2010 task force criteria on reclassification of cardiovascular magnetic resonance criteria for arrhythmogenic right ventricular cardiomyopathy. Journal of Cardiovascular Magnetic Resonance, 16(1), [47]. https://doi.org/10.1186/1532-429X-16-47