Effect of the environment on the dendritic morphology of the rat auditory cortex

Mitali Bose, Pablo Muñoz-Llancao, Swagata Roychowdhury, Justin A. Nichols, Vikram Jakkamsetti, Benjamin Porter, Rajasekhar Byrapureddy, Humberto Salgado, Michael P. Kilgard, Francisco Aboitiz, Alexies Dagnino-Subiabre, Marco Atzori

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The present study aimed to identify morphological correlates of environment-induced changes at excitatory synapses of the primary auditory cortex (A1). We used the Golgi-Cox stain technique to compare pyramidal cells dendritic properties of Sprague-Dawley rats exposed to different environmental manipulations. Sholl analysis, dendritic length measures, and spine density counts were used to monitor the effects of sensory deafness and an auditory version of environmental enrichment (EE). We found that deafness decreased apical dendritic length leaving basal dendritic length unchanged, whereas EE selectively increased basal dendritic length without changing apical dendritic length. On the contrary, deafness decreased while EE increased spine density in both basal and apical dendrites of A1 Layer 2/3 (LII/III) neurons. To determine whether stress contributed to the observed morphological changes in A1, we studied neural morphology in a restraint-induced model that lacked behaviorally relevant acoustic cues. We found that stress selectively decreased apical dendritic length in the auditory but not in the visual primary cortex. Similar to the acoustic manipulation, stress-induced changes in dendritic length possessed a layer-specific pattern displaying LII/III neurons from stressed animals with normal apical dendrites but shorter basal dendrites, while infragranular neurons (Layers V and VI) displayed shorter apical dendrites but normal basal dendrites. The same treatment did not induce similar changes in the visual cortex, demonstrating that the auditory cortex is an exquisitely sensitive target of neocortical plasticity, and that prolonged exposure to different acoustic as well as emotional environmental manipulation may produce specific changes in dendritic shape and spine density.

Original languageEnglish (US)
Pages (from-to)97-110
Number of pages14
JournalSynapse
Volume64
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Auditory Cortex
Dendrites
Deafness
Acoustics
Visual Cortex
Neurons
Spine
Dendritic Spines
Pyramidal Cells
Synapses
Cues
Sprague Dawley Rats
Coloring Agents

Keywords

  • Deafness
  • Depression
  • Enrichment
  • Sensory deprivation
  • Spines
  • Stress
  • Visual cortex

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Bose, M., Muñoz-Llancao, P., Roychowdhury, S., Nichols, J. A., Jakkamsetti, V., Porter, B., ... Atzori, M. (2010). Effect of the environment on the dendritic morphology of the rat auditory cortex. Synapse, 64(2), 97-110. https://doi.org/10.1002/syn.20710

Effect of the environment on the dendritic morphology of the rat auditory cortex. / Bose, Mitali; Muñoz-Llancao, Pablo; Roychowdhury, Swagata; Nichols, Justin A.; Jakkamsetti, Vikram; Porter, Benjamin; Byrapureddy, Rajasekhar; Salgado, Humberto; Kilgard, Michael P.; Aboitiz, Francisco; Dagnino-Subiabre, Alexies; Atzori, Marco.

In: Synapse, Vol. 64, No. 2, 01.02.2010, p. 97-110.

Research output: Contribution to journalArticle

Bose, M, Muñoz-Llancao, P, Roychowdhury, S, Nichols, JA, Jakkamsetti, V, Porter, B, Byrapureddy, R, Salgado, H, Kilgard, MP, Aboitiz, F, Dagnino-Subiabre, A & Atzori, M 2010, 'Effect of the environment on the dendritic morphology of the rat auditory cortex', Synapse, vol. 64, no. 2, pp. 97-110. https://doi.org/10.1002/syn.20710
Bose M, Muñoz-Llancao P, Roychowdhury S, Nichols JA, Jakkamsetti V, Porter B et al. Effect of the environment on the dendritic morphology of the rat auditory cortex. Synapse. 2010 Feb 1;64(2):97-110. https://doi.org/10.1002/syn.20710
Bose, Mitali ; Muñoz-Llancao, Pablo ; Roychowdhury, Swagata ; Nichols, Justin A. ; Jakkamsetti, Vikram ; Porter, Benjamin ; Byrapureddy, Rajasekhar ; Salgado, Humberto ; Kilgard, Michael P. ; Aboitiz, Francisco ; Dagnino-Subiabre, Alexies ; Atzori, Marco. / Effect of the environment on the dendritic morphology of the rat auditory cortex. In: Synapse. 2010 ; Vol. 64, No. 2. pp. 97-110.
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