Effectiveness of a six‐drug regimen (APO) without local irradiation for treatment of mediastinal lymphoblastic lymphoma in children

Bruce M. Camitta, Stephen J. Lauer, James T. Casper, Phyllis A. Kirchner, Larry E. Kun, Herbert W. Oechler, Stuart E. Adair

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Fourteen children with mediastinal lymphoblastic lymphoma (MLL) were treated with the six‐drug APO protocol. This regimen includes aggressive intermittent chemotherapy and prophylactic central nervous system therapy. Mediastinal irradiation was given only for emergency relief of mediastinal compression (two children) or for incomplete resolution of mediastinal widening with chemotherapy (one child). All 14 patients achieved complete remission; only 1 has relapsed. Toxicities were not severe. APO is effective therapy for children with MLL. APO should receive further trials in children and adults with T‐cell lymphoblastic lymphomas.

Original languageEnglish (US)
Pages (from-to)738-741
Number of pages4
JournalCancer
Volume56
Issue number4
DOIs
StatePublished - Aug 15 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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