Fourteen children with mediastinal lymphoblastic lymphoma (MLL) were treated with the six‐drug APO protocol. This regimen includes aggressive intermittent chemotherapy and prophylactic central nervous system therapy. Mediastinal irradiation was given only for emergency relief of mediastinal compression (two children) or for incomplete resolution of mediastinal widening with chemotherapy (one child). All 14 patients achieved complete remission; only 1 has relapsed. Toxicities were not severe. APO is effective therapy for children with MLL. APO should receive further trials in children and adults with T‐cell lymphoblastic lymphomas.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Aug 15 1985|
ASJC Scopus subject areas
- Cancer Research