Effects of Common Laser Treatments on Hyaluronic Acid Fillers in a Porcine Model

Jordan P. Farkas, James A. Richardson, Spencer Brown, John E. Hoopman, Jeffrey M. Kenkel

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Injectable hyaluronic acid fillers (HAFs) and laser/light procedures have become increasingly popular for noninvasive facial rejuvenation in many cosmetic practices. However, the effect of laser/light treatments on HAFs is unknown. Objective: Our objective was to examine the effect of laser/light treatments on HAFs in a porcine model. Methods: The abdomens of 6 Yorkshire pigs were injected with 3 different HAFs: Restylane (Medicis, Scottsdale, AZ), Perlane (Medicis), and Juvéderm (Allergan, Santa Barbara, CA). Two weeks after injection, the injection sites were treated with 1 of 7 common laser/light ablative or nonablative devices. Following laser treatment, 8-mm punch biopsies were collected from the treated tissue and fixed for histopathologic evaluation. Sections were stained with hematoxylin-eosin and alcian blue stains for identification of the preinjected HAF. Results: The filler was identified in different areas of the dermis in different sections. The Sciton intense pulsed 560 nm filter (Sciton, Palo Alto, CA), the Sciton Nd: YAG, Lux1540 (Palomar Medical Technologies, Burlington, MA), or ActiveFX (Lumenis, Yokneum, Israel) treatments showed no sign of interaction with superficial or deep dermal filler. No evidence of morphologic changes to the filler or the surrounding tissues was observed. Obvious interaction between the HAFs and the laser injury was demonstrated in sections treated with the deep ablative systems fractional erbium 2940 (Profractional; Sciton) and DeepFX CO2, (Lumenis). However, no uncharacteristic tissue injury or morphologic change in the filler was appreciated in any of the preinjected specimens. Conclusions: Injected HAFs were unaffected by the nonablative laser/light and superficial ablative treatments. The more aggressive deeper laser treatments demonstrated laser/filler interaction and may have a clinical effect on the longevity of the filler and/or efficacy of laser treatments. Novel ablative fractional lasers have the capability of deep dermal penetration, and this should be taken into consideration when planning to use them in combination with soft tissue fillers for noninvasive facial rejuvenation.

Original languageEnglish (US)
Pages (from-to)503-511
Number of pages9
JournalAesthetic Surgery Journal
Volume28
Issue number5
DOIs
StatePublished - Sep 2008

Fingerprint

Hyaluronic Acid
Lasers
Swine
Light
Therapeutics
Rejuvenation
Injections
Erbium
Alcian Blue
Wounds and Injuries
Israel
Hematoxylin
Eosine Yellowish-(YS)
Dermis
Cosmetics
Abdomen
Coloring Agents
Technology
Biopsy
Equipment and Supplies

ASJC Scopus subject areas

  • Surgery

Cite this

Effects of Common Laser Treatments on Hyaluronic Acid Fillers in a Porcine Model. / Farkas, Jordan P.; Richardson, James A.; Brown, Spencer; Hoopman, John E.; Kenkel, Jeffrey M.

In: Aesthetic Surgery Journal, Vol. 28, No. 5, 09.2008, p. 503-511.

Research output: Contribution to journalArticle

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AU - Kenkel, Jeffrey M.

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