TY - JOUR
T1 - Effects of exercise training on arterial-cardiac baroreflex function in POTS
AU - Galbreath, M. Melyn
AU - Shibata, Shigeki
AU - VanGundy, Tiffany B.
AU - Okazaki, Kazunobu
AU - Fu, Qi
AU - Levine, Benjamin D
N1 - Funding Information:
Acknowledgments We would like to give special thanks to Robin P. Shook, M. Dean Palmer, Colin L. Conner, Daniel L. Creson, Diane Bedenkop, Peggy Fowler, Murugappan Ramanathan, Cyrus Oufi, Dak Quarles, and Rhonda L. Meier for their valuable laboratory assistance. We are especially grateful for the subjects that volunteered to be a part of this study. This study was supported by the NIH K23 (HL0752 83), National Space Biomedical Research Institute grant (CA00701), and GCRC grant (RR00633).
PY - 2011/4
Y1 - 2011/4
N2 - Purpose Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive tachycardia in the upright position. To test the hypothesis that patients with POTS have impaired arterial-cardiac baroreflex function, while exercise training normalizes the baroreflex function in these patients. Methods Seventeen POTS patients aged 27 ± 9 (mean ± SD) years underwent an exercise training program for 3 months. Arterial-cardiac baroreflex function was assessed by spectral and transfer function analysis of beat-tobeat R-R interval (RRI) and systolic blood pressure (SBP) variability in the supine position and at 60° upright tilt during spontaneous breathing before and after training. Data were compared with 17 healthy sedentary controls. Results Even though upright heart rate (HR) was greater in patients than controls, indexes of RRI variability did not differ between groups. Transfer function gain (SBP toRRI), used as an index of arterial-cardiac baroreflex sensitivity was similar between patients and controls in bothlow- (LF, P = 0.470) and high-frequency (HF, P = 0.663) ranges. Short-term exercise training decreased upright HR and increased RRI variability in POTS patients. LF baroreflex gain increased significantly in the supine position and during upright tilt [analysis of variance (ANOVA), P = 0.04 for training], while HF gain increased modestly after training (ANOVA, P = 0.105 for training) in these patients; however, the baroreflex gains remained within the normal ranges when compared with healthy controls. Conclusions These data suggest that patients with POTS have normal arterial-cardiac baroreflex function in both supine and upright postures. Short-term exercise training increases the baroreflex sensitivity in these patients, associated with a decrease in upright heart rate.
AB - Purpose Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive tachycardia in the upright position. To test the hypothesis that patients with POTS have impaired arterial-cardiac baroreflex function, while exercise training normalizes the baroreflex function in these patients. Methods Seventeen POTS patients aged 27 ± 9 (mean ± SD) years underwent an exercise training program for 3 months. Arterial-cardiac baroreflex function was assessed by spectral and transfer function analysis of beat-tobeat R-R interval (RRI) and systolic blood pressure (SBP) variability in the supine position and at 60° upright tilt during spontaneous breathing before and after training. Data were compared with 17 healthy sedentary controls. Results Even though upright heart rate (HR) was greater in patients than controls, indexes of RRI variability did not differ between groups. Transfer function gain (SBP toRRI), used as an index of arterial-cardiac baroreflex sensitivity was similar between patients and controls in bothlow- (LF, P = 0.470) and high-frequency (HF, P = 0.663) ranges. Short-term exercise training decreased upright HR and increased RRI variability in POTS patients. LF baroreflex gain increased significantly in the supine position and during upright tilt [analysis of variance (ANOVA), P = 0.04 for training], while HF gain increased modestly after training (ANOVA, P = 0.105 for training) in these patients; however, the baroreflex gains remained within the normal ranges when compared with healthy controls. Conclusions These data suggest that patients with POTS have normal arterial-cardiac baroreflex function in both supine and upright postures. Short-term exercise training increases the baroreflex sensitivity in these patients, associated with a decrease in upright heart rate.
KW - Arterial pressure
KW - Baroreflex function
KW - Orthostatic intolerance
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U2 - 10.1007/s10286-010-0091-5
DO - 10.1007/s10286-010-0091-5
M3 - Article
C2 - 21103906
AN - SCOPUS:79958770047
SN - 0959-9851
VL - 21
SP - 73
EP - 80
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
IS - 2
ER -