Effects of low dose chenodeoxycholic acid feeding on biliary lipid metabolism

R. D. Adler, L. J. Bennion, W. C. Duane, Scott M Grundy

Research output: Contribution to journalArticle

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Abstract

To better define the mechanisms by which chenodeoxycholic acid (CDCA) alters the lipid composition of bile and promotes dissolution of cholesterol gallstones, the effects of relatively low doses of CDCA on the metabolism of biliary lipids were studied in 10 subjects without gallstones. In 5 subjects, the effects of CDCA feeding were compared to those of cholic acid, a bile acid that apparently does not dissolve cholesterol stones. The following measurements were carried out during control and treatment periods: composition of biliary lipids, hepatic secretion rates of biliary lipids, pool sizes of bile acids, and specific composition of bile acids. Low doses of CDCA consistently reduced the lithogenicity of gallbladder bile by decreasing the proportion of cholesterol relative to the solubilizing lipids - bile acids and lecithin. This decrease in lithogenicity was associated with a selective reduction in hepatic secretion rates of cholesterol. At the doses of CDCA given secretion rates of bile acids and lecithin and pool sizes of bile acids were not significantly changed; also conversion of cholesterol into bile acids was not completely inhibited. Cholic acid feeding appeared to increase the total size of the bile acid pool, but it did not affect the lithogenicity of bile or secretion rates of cholesterol. The data show that at low doses CDCA lowers lithogenicity of bile by reducing hepatic secretion of cholesterol, while cholic acid does not have a similar effect.

Original languageEnglish (US)
Pages (from-to)326-334
Number of pages9
JournalGastroenterology
Volume68
Issue number2
StatePublished - 1975

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Chenodeoxycholic Acid
Bile Acids and Salts
Lipid Metabolism
Cholesterol
Cholic Acid
Bile
Lipids
Lecithins
Gallstones
Liver
Gallbladder

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effects of low dose chenodeoxycholic acid feeding on biliary lipid metabolism. / Adler, R. D.; Bennion, L. J.; Duane, W. C.; Grundy, Scott M.

In: Gastroenterology, Vol. 68, No. 2, 1975, p. 326-334.

Research output: Contribution to journalArticle

Adler, RD, Bennion, LJ, Duane, WC & Grundy, SM 1975, 'Effects of low dose chenodeoxycholic acid feeding on biliary lipid metabolism', Gastroenterology, vol. 68, no. 2, pp. 326-334.
Adler, R. D. ; Bennion, L. J. ; Duane, W. C. ; Grundy, Scott M. / Effects of low dose chenodeoxycholic acid feeding on biliary lipid metabolism. In: Gastroenterology. 1975 ; Vol. 68, No. 2. pp. 326-334.
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