Effects of nicotine on uterine blood flow and intrauterine oxygen tension in the rat

Robert E Hammer, H. Goldman, J. A. Mitchell

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Subcutaneous injection of nicotine (0.5 or 5 mg/kg body wt) resulted in a marked and prolonged reduction in uterine blood flow and intrauterine oxygen tension in pseudopregnant rats. By 10 min after nicotine administration (5 mg/kg) uterine perfusion was reduced by 40%, remained suppressed for 90 min and returned to the pre-treatment level by 120 min. Rats receiving the 0.5 mg nicotine/kg also showed a marked reduction in uterine blood flow, although the response was slower in onset and longer in duration. Nicotine (5 mg/kg) also resulted in a sustained decrease in intrauterine oxygen tension from a control value of 48.9 ± 3.6 to 22.2 ± 2.6 mmHg at 45-60 min and 21.7 ± 1.5 mmHg at 60-90 min. The frequency and amplitude of fluctuations in intrauterine oxygen tension were still reduced by 90 min after treatment.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalJournal of Reproduction and Fertility
Volume63
Issue number1
StatePublished - 1981

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Nicotine
Oxygen
Subcutaneous Injections
Perfusion
Therapeutics

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Physiology
  • Embryology
  • Obstetrics and Gynecology

Cite this

Effects of nicotine on uterine blood flow and intrauterine oxygen tension in the rat. / Hammer, Robert E; Goldman, H.; Mitchell, J. A.

In: Journal of Reproduction and Fertility, Vol. 63, No. 1, 1981, p. 163-168.

Research output: Contribution to journalArticle

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