Abstract
Subcutaneous injection of nicotine (0.5 or 5 mg/kg body wt) resulted in a marked and prolonged reduction in uterine blood flow and intrauterine oxygen tension in pseudopregnant rats. By 10 min after nicotine administration (5 mg/kg) uterine perfusion was reduced by 40%, remained suppressed for 90 min and returned to the pre-treatment level by 120 min. Rats receiving the 0.5 mg nicotine/kg also showed a marked reduction in uterine blood flow, although the response was slower in onset and longer in duration. Nicotine (5 mg/kg) also resulted in a sustained decrease in intrauterine oxygen tension from a control value of 48.9 ± 3.6 to 22.2 ± 2.6 mmHg at 45-60 min and 21.7 ± 1.5 mmHg at 60-90 min. The frequency and amplitude of fluctuations in intrauterine oxygen tension were still reduced by 90 min after treatment.
Original language | English (US) |
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Pages (from-to) | 163-168 |
Number of pages | 6 |
Journal | Journal of Reproduction and Fertility |
Volume | 63 |
Issue number | 1 |
DOIs | |
State | Published - 1981 |
ASJC Scopus subject areas
- Physiology
- Embryology
- Molecular Biology
- Obstetrics and Gynecology
- Developmental Biology