Effects of passive heating on central blood volume and ventricular dimensions in humans

Craig G. Crandall, T. E. Wilson, J. Marving, T. W. Vogelsang, A. Kjaer, B. Hesse, N. H. Secher

Research output: Contribution to journalArticle

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Abstract

Mixed findings regarding the effects of whole-body heat stress on central blood volume have been reported. This study evaluated the hypothesis that heat stress reduces central blood volume and alters blood volume distribution. Ten healthy experimental and seven healthy time control (i.e. non-heat stressed) subjects participated in this protocol. Changes in regional blood volume during heat stress and time control were estimated using technetium-99m labelled autologous red blood cells and gamma camera imaging. Whole-body heating increased internal temperature (> 1.0°C), cutaneous vascular conductance (approximately fivefold), and heart rate (52 ± 2 to 93 ± 4 beats min-1), while reducing central venous pressure (5.5 ± 07 to 0.2 ± 0.6 mmHg) accompanied by minor decreases in mean arterial pressure (all P < 0.05). The heat stress reduced the blood volume of the heart (18 ± 2%), heart plus central vasculature (17 ± 2%), thorax (14 ± 2%), inferior vena cava (23 ± 2%) and liver (23 ± 2%) (all P ≤ 0.005 relative to time control subjects). Radionuclide multiple-gated acquisition assessment revealed that heat stress did not significantly change left ventricular end-diastolic volume, while ventricular end-systolic volume was reduced by 24 ± 6% of pre-heat stress levels (P < 0.001 relative to time control subjects). Thus, heat stress increased left ventricular ejection fraction from 60 ± 1% to 68 ± 2% (P = 0.02). We conclude that heat stress shifts blood volume from thoracic and splanchnic regions presumably to aid in heat dissipation, while simultaneously increasing heart rate and ejection fraction.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalJournal of Physiology
Volume586
Issue number1
DOIs
StatePublished - Jan 1 2008

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Blood Volume
Heating
Hot Temperature
Stroke Volume
Thorax
Heart Rate
Central Venous Pressure
Viscera
Technetium
Inferior Vena Cava
Radioisotopes
Radionuclide Imaging
Blood Vessels
Arterial Pressure
Erythrocytes
Skin
Temperature
Liver

ASJC Scopus subject areas

  • Physiology

Cite this

Crandall, C. G., Wilson, T. E., Marving, J., Vogelsang, T. W., Kjaer, A., Hesse, B., & Secher, N. H. (2008). Effects of passive heating on central blood volume and ventricular dimensions in humans. Journal of Physiology, 586(1), 293-301. https://doi.org/10.1113/jphysiol.2007.143057

Effects of passive heating on central blood volume and ventricular dimensions in humans. / Crandall, Craig G.; Wilson, T. E.; Marving, J.; Vogelsang, T. W.; Kjaer, A.; Hesse, B.; Secher, N. H.

In: Journal of Physiology, Vol. 586, No. 1, 01.01.2008, p. 293-301.

Research output: Contribution to journalArticle

Crandall, CG, Wilson, TE, Marving, J, Vogelsang, TW, Kjaer, A, Hesse, B & Secher, NH 2008, 'Effects of passive heating on central blood volume and ventricular dimensions in humans', Journal of Physiology, vol. 586, no. 1, pp. 293-301. https://doi.org/10.1113/jphysiol.2007.143057
Crandall, Craig G. ; Wilson, T. E. ; Marving, J. ; Vogelsang, T. W. ; Kjaer, A. ; Hesse, B. ; Secher, N. H. / Effects of passive heating on central blood volume and ventricular dimensions in humans. In: Journal of Physiology. 2008 ; Vol. 586, No. 1. pp. 293-301.
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