The present study was undertaken to determine the direct effects of propranolol on coronary blood flow in ischemic tissue under constant hemodynamic conditions. In this study a brief period of total coronary occlusion followed by partial restriction of coronary inflow to the ischemic region resulted in a transmural maldistribution of myocardial flow and subendocardial ischemia. This model of transient subendocardial ischemia was employed because it is reproducible and results in less severe alterations in hemodynamic state and the experimental model is more closely analogous to the transient myocardial ischemia experienced by patients with angina pectoris than a model utilizing permanent total occlusion. The mechanism of action of propranolol was further investigated by comparing the effects of racemic propranolol with those of d-propranolol, a stereoisomer with membrane stabilizing effects similar to propranolol but with only minimal beta-blocking effects. The study was performed in conscious dogs to eliminate the effects of anesthesia and acute surgery on coronary blood flow and sympathetic tone.
|Original language||English (US)|
|Title of host publication||Transactions of the Association of American Physicians|
|Number of pages||12|
|State||Published - 1979|
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