The effects of various neuroleptics were studied on N,N-dimethyltryptamine (DMT, 3.2 mg/kg) and d-amphetamine (3.2 mg/kg) induced hyperthermia in the rabbit. Complete dose-effect curves were obtained. The order of potency for antagonism of DMT-induced hyperthermia was: methiothepin > octoclothepin ≥ oxyprothepin > perathiepin > dokloxythepin > mianserine > loxapine > oxypertine > chlorpromazine > pipamperone > fluphenazine > thiothixene > haloperidol > molindone. The order of potency for antagonism of d-amphetamine hyperthermia was: haloperidol > chlorpromazine > oxypertine > octoclothepin and methiothepin. For these five drugs, the order of potency for antagonism of amphetamine hyperthermia was the reverse of the order for antagonism of DMT hyperthermia. Methiothepin reduced d-amphetamine-induced hyperthermia effectively at a very high dose (0.32 mg/kg) and variably at lower doses. The results indicate that neuroleptics differ markedly in their specificity of antagonism of DMT and d-amphetamine which may act through different neurotransmitter mechanisms (tryptaminergic vs. adrenergic).
|Original language||English (US)|
|Number of pages||18|
|Journal||Archives internationales de pharmacodynamie et de therapie|
|State||Published - Dec 1 1977|
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