Efficient N-arylation of pyridazin-3(2H)-ones

Jeum Jong Kim, Yong Dae Park, Su Dong Cho, Ho Kyun Kim, Hyun A. Chung, Sang Gyeong Lee, J. R. Falck, Yong Jin Yoon

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A variety of substituted pyridazin-3(2H)-ones are directly N-arylated in good yield using lead tetraacetate/zinc chloride in benzene or in substituted benzenes including chloro- and bromobenzene. A variety of substituted pyridazin-3(2H)-ones are directly N-arylated in good yield using lead tetraacetate/zinc chloride in benzene or in substituted benzenes including chloro- and bromobenzene.

Original languageEnglish (US)
Pages (from-to)8781-8784
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number48
DOIs
StatePublished - Nov 22 2004

Keywords

  • Lead tetraacetate
  • N-Arylation
  • Pyridazin-3(2H)-ones
  • Zinc chloride

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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