Abstract
The electrochemical oxidation of several 1-benzyl tetrahydroisoquinolines has been performed at a platinum anode in acetonitrile. Using potentiostatic conditions and a three compartment cell, the following cyclizations were accomplished on a several hundred milligram scale in the yields indicated: 6′-bromolaudanosine to O-methylflavinantine (16%), 5′-methoxylaudanosine to O-methyl-C-norandrocymbine (38%), 8-methoxylaudanosine to protostephanone (35%), norlaudanosine to N-nor-O-methylflavinantine (22%).
Original language | English (US) |
---|---|
Pages (from-to) | 931-934 |
Number of pages | 4 |
Journal | Tetrahedron |
Volume | 30 |
Issue number | 8 |
DOIs | |
State | Published - 1974 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry