TY - JOUR
T1 - Electrophysiological correlates of emotional scene processing in bipolar disorder
AU - Trotti, Rebekah L.
AU - Parker, David A.
AU - Sabatinelli, Dean
AU - Tamminga, Carol A.
AU - Gershon, Elliot S.
AU - Keedy, Sarah K.
AU - Keshavan, Matcheri S.
AU - Pearlson, Godfrey D.
AU - Sweeney, John A.
AU - McDowell, Jennifer E.
AU - Clementz, Brett A.
N1 - Funding Information:
This work was supported by the National Institute of Mental Health at the National Institutes of Health (grant numbers MH096942 , MH078113 , MH096900 , MH103366 , MH096913 , MH077851 , MH096957 , MH077945 , MH103368 ). The funder had no role in study design, data collection, data analysis and interpretation, writing of the report, or in the decision to submit the article for publication.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/1
Y1 - 2020/1
N2 - Emotional dysfunction is a core feature of bipolar I disorder (BD). Behavioral data suggest that emotional processing may differ based on history of psychosis, but physiological studies frequently disregard this differentiating feature. Face processing studies indicate that emotion-related components of event-related potentials (ERPs) are abnormal in BD, but fMRI data using emotional scenes are mixed. The current study used ERPs to examine emotional scene perception in BD with and without a history of psychosis (BDP, BDNP). 386 participants from the PARDIP consortium (HC = 181, BDP = 130, BDNP = 75) viewed neutral, pleasant, and unpleasant scenes from the International Affective Picture System (IAPS) during continuous EEG recording. The early posterior negativity (EPN) and late positive potential (LPP) were examined for group and stimulus effects. Analyses were conducted for groups on and off medications to examine associations between medication status, psychosis, and ERP response. Group differences were found between HC and BD in emotional modulation of the EPN and between HC and BDP in the LPP to pleasant images. There was a significant interaction between psychosis history and anticonvulsant status in the EPN, but no other medication associations were found. The relationship between neural/self-reported emotional responses and clinical symptoms were examined with canonical correlations, but no significant associations were found. Results from this large well characterized sample indicate mild deviations in neural reactivity related to medication, mood, and psychosis history. However, processing of emotional scenes appears mostly intact in individuals with BD regardless of symptom severity.
AB - Emotional dysfunction is a core feature of bipolar I disorder (BD). Behavioral data suggest that emotional processing may differ based on history of psychosis, but physiological studies frequently disregard this differentiating feature. Face processing studies indicate that emotion-related components of event-related potentials (ERPs) are abnormal in BD, but fMRI data using emotional scenes are mixed. The current study used ERPs to examine emotional scene perception in BD with and without a history of psychosis (BDP, BDNP). 386 participants from the PARDIP consortium (HC = 181, BDP = 130, BDNP = 75) viewed neutral, pleasant, and unpleasant scenes from the International Affective Picture System (IAPS) during continuous EEG recording. The early posterior negativity (EPN) and late positive potential (LPP) were examined for group and stimulus effects. Analyses were conducted for groups on and off medications to examine associations between medication status, psychosis, and ERP response. Group differences were found between HC and BD in emotional modulation of the EPN and between HC and BDP in the LPP to pleasant images. There was a significant interaction between psychosis history and anticonvulsant status in the EPN, but no other medication associations were found. The relationship between neural/self-reported emotional responses and clinical symptoms were examined with canonical correlations, but no significant associations were found. Results from this large well characterized sample indicate mild deviations in neural reactivity related to medication, mood, and psychosis history. However, processing of emotional scenes appears mostly intact in individuals with BD regardless of symptom severity.
KW - Bipolar disorders
KW - Electroencephalography
KW - Emotional processing
KW - Psychosis
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U2 - 10.1016/j.jpsychires.2019.10.005
DO - 10.1016/j.jpsychires.2019.10.005
M3 - Article
C2 - 31634753
AN - SCOPUS:85073337528
SN - 0022-3956
VL - 120
SP - 83
EP - 90
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -