Elevated serum IL-8 is associated with the presence of hepatocellular carcinoma and independently predicts survival

Theodore H. Welling, Sherry Fu, Shanshan Wan, Weiping Zou, Jorge A. Marrero

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Tumor immune responses have prognostic importance to hepatocellular carcinoma (HCC). Serum cytokines may differentiate HCC patients from cirrhotic patients or have prognostic significance. Serum IL-8 was elevated in 90 HCC patients compared to 180 cirrhotic controls, whereas IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-15, IL-17, IL-21, and VEGF were similar. IL-8 predicted HCC presence with an area under the receiver-operator curve (ROC) of 0.68. HCC patients with highest IL-8 had worse survival. Multivariate analysis showed that high IL-8 (HR 2.15; 95%CI:1.21-3.74) and stage (HR 1.92; 95%CI:1.22-3.97) independently predicted mortality; while viral etiology was protective (HR 0.69; 95%CI:0.41-0.98). Therefore, HCC IL-8 mediated events may be worthy of future investigation.

Original languageEnglish (US)
Pages (from-to)689-697
Number of pages9
JournalCancer Investigation
Volume30
Issue number10
DOIs
StatePublished - Dec 2012

Keywords

  • Cancer biology
  • Cirrhosis
  • Hepatocellular carcinoma
  • Inflammation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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