Elevated White Blood Cell Levels and Thrombotic Events in Patients With Polycythemia Vera: A Real-World Analysis of Veterans Health Administration Data

Shreekant Parasuraman; Jingbo Yu; Dilan Paranagama; Sulena Shrestha; Li Wang; Onur Baser; Robyn Scherber

doi:10.1016/j.clml.2019.11.010

Elevated White Blood Cell Levels and Thrombotic Events in Patients With Polycythemia Vera: A Real-World Analysis of Veterans Health Administration Data

Shreekant Parasuraman, Jingbo Yu, Dilan Paranagama, Sulena Shrestha, Li Wang, Onur Baser, Robyn Scherber

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Patients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). In the present retrospective analysis using Veterans Health Administration claims data, 25% of 1565 patients experienced a TE during follow-up. We observed a positive, significant association between white blood cell (WBC) counts ≥ 8.5 × 10⁹/L and TE occurrence (reference, WBC count < 7.0 × 10⁹/L), supporting continued inclusion of WBC count control in disease management.

Original language	English (US)
Pages (from-to)	63-69
Number of pages	7
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.clml.2019.11.010
State	Published - Feb 2020
Externally published	Yes

Keywords

Leukocytosis
Retrospective analysis
Thrombosis
White blood cell count

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.clml.2019.11.010

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title = "Elevated White Blood Cell Levels and Thrombotic Events in Patients With Polycythemia Vera: A Real-World Analysis of Veterans Health Administration Data",

abstract = "Patients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). In the present retrospective analysis using Veterans Health Administration claims data, 25% of 1565 patients experienced a TE during follow-up. We observed a positive, significant association between white blood cell (WBC) counts ≥ 8.5 × 109/L and TE occurrence (reference, WBC count < 7.0 × 109/L), supporting continued inclusion of WBC count control in disease management.",

keywords = "Leukocytosis, Retrospective analysis, Thrombosis, White blood cell count",

author = "Shreekant Parasuraman and Jingbo Yu and Dilan Paranagama and Sulena Shrestha and Li Wang and Onur Baser and Robyn Scherber",

note = "Funding Information: The present study and writing support were funded by Incyte Corporation (Wilmington, DE). The study design and data collection, analysis, and interpretation were conducted by us, some of whom are employees of Incyte Corporation. Editorial assistance was provided by Wendy van der Spuy, PhD (Complete Healthcare Communications, LLC [North Wales, PA], a CHC Group Company). Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2020",

month = feb,

doi = "10.1016/j.clml.2019.11.010",

language = "English (US)",

volume = "20",

pages = "63--69",

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T2 - A Real-World Analysis of Veterans Health Administration Data

AU - Parasuraman, Shreekant

AU - Yu, Jingbo

AU - Paranagama, Dilan

AU - Shrestha, Sulena

AU - Wang, Li

AU - Baser, Onur

AU - Scherber, Robyn

N1 - Funding Information: The present study and writing support were funded by Incyte Corporation (Wilmington, DE). The study design and data collection, analysis, and interpretation were conducted by us, some of whom are employees of Incyte Corporation. Editorial assistance was provided by Wendy van der Spuy, PhD (Complete Healthcare Communications, LLC [North Wales, PA], a CHC Group Company). Publisher Copyright: © 2019 The Authors

PY - 2020/2

Y1 - 2020/2

N2 - Patients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). In the present retrospective analysis using Veterans Health Administration claims data, 25% of 1565 patients experienced a TE during follow-up. We observed a positive, significant association between white blood cell (WBC) counts ≥ 8.5 × 109/L and TE occurrence (reference, WBC count < 7.0 × 109/L), supporting continued inclusion of WBC count control in disease management.

AB - Patients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). In the present retrospective analysis using Veterans Health Administration claims data, 25% of 1565 patients experienced a TE during follow-up. We observed a positive, significant association between white blood cell (WBC) counts ≥ 8.5 × 109/L and TE occurrence (reference, WBC count < 7.0 × 109/L), supporting continued inclusion of WBC count control in disease management.

KW - Leukocytosis

KW - Retrospective analysis

KW - Thrombosis

KW - White blood cell count

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Elevated White Blood Cell Levels and Thrombotic Events in Patients With Polycythemia Vera: A Real-World Analysis of Veterans Health Administration Data

Abstract

Keywords

ASJC Scopus subject areas

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