ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL

Stephanie E. Kong; Charles A.S. Banks; Ali Shilatifard; Joan Weliky Conaway; Ronald C. Conaway

doi:10.1073/pnas.0503017102

ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL

Stephanie E. Kong, Charles A.S. Banks, Ali Shilatifard, Joan Weliky Conaway, Ronald C. Conaway

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase II transcription.

Original language	English (US)
Pages (from-to)	10094-10098
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	102
Issue number	29
DOIs	https://doi.org/10.1073/pnas.0503017102
State	Published - Jul 19 2005
Externally published	Yes

Keywords

Elongation
Transcription
Transcription factor
mRNA synthesis

ASJC Scopus subject areas

General

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10.1073/pnas.0503017102

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title = "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL",

abstract = "In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase II transcription.",

keywords = "Elongation, Transcription, Transcription factor, mRNA synthesis",

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doi = "10.1073/pnas.0503017102",

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T1 - ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL

AU - Kong, Stephanie E.

AU - Banks, Charles A.S.

AU - Shilatifard, Ali

AU - Conaway, Joan Weliky

AU - Conaway, Ronald C.

PY - 2005/7/19

Y1 - 2005/7/19

N2 - In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase II transcription.

AB - In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase II transcription.

KW - Elongation

KW - Transcription

KW - Transcription factor

KW - mRNA synthesis

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EP - 10098

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 29

ER -

ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL

Abstract

Keywords

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