Emerging ethical challenges raised by the evolution of vascularized composite allotransplantation

Arthur L. Caplan, Brendan Parent, Jeffrey Kahn, Wendy Dean, Laura L. Kimberly, W. P.Andrew Lee, Eduardo D. Rodriguez

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background. Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplants to how to conduct them ethically. Methods. Leaders of each program performing and/or evaluating VCA in the United States were invited to participate in a working group to assess the state and future of VCA ethics and policy. Four meetings were held over the course of 1 year to describe key challenges and potential solutions. Results. Working group participants concluded that VCA holds great promise as treatment for patients with particular injuries or deficits, but the field faces unique challenges to adoption as standard of care, which can only be overcome by data sharing and standardization of evaluation and outcome metrics. Conclusions. Adequate attention must be given to concerns including managing the uniquely intense physician-patient relationship, ethical patient selection, ensuring patients have adequate representation, informing and earning the trust of the public for donation, standardizing metrics for success, and fostering an environment of data sharing. These steps are critical to transitioning VCA from research to standard of care and to its insurance coverage inclusion.

Original languageEnglish (US)
Pages (from-to)1240-1246
Number of pages7
JournalTransplantation
Volume103
Issue number6
DOIs
StatePublished - Jun 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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  • Cite this

    Caplan, A. L., Parent, B., Kahn, J., Dean, W., Kimberly, L. L., Lee, W. P. A., & Rodriguez, E. D. (2019). Emerging ethical challenges raised by the evolution of vascularized composite allotransplantation. Transplantation, 103(6), 1240-1246. https://doi.org/10.1097/TP.0000000000002478