Enantioselective reduction of ketones and imines catalyzed by (CN-Box)ReV-oxo complexes

Kristine A. Nolin, Richard W. Ahn, Yusuke Kobayashi, Joshua J. Kennedy-Smith, F. Dean Toste

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

The development and application of chiral, non-racemic ReV-oxo complexes to the enantioselective reduction of prochiral ketones is described. In addition to the enantioselective reduction of prochiral ketones, we report the application of these complexes to 1) a tandem Meyer-Schuster rearrangement/reduction to access enantioenriched allylic alcohols and 2) the enantioselective reduction of imines.

Original languageEnglish (US)
Pages (from-to)9555-9562
Number of pages8
JournalChemistry - A European Journal
Volume16
Issue number31
DOIs
StatePublished - Aug 16 2010
Externally publishedYes

Keywords

  • Enantioselective reduction
  • Hydrosilylation
  • Rearrangement
  • Rhenium

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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