TY - JOUR
T1 - Endometrial Glandular Dysplasia (EmGD)
T2 - Morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers
AU - Fadare, Oluwole
AU - Zheng, Wenxin
N1 - Funding Information:
The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Defense or other Departments of the United States Government. This work is supported in part by P30 CA23074 and the University of Arizona Department of Pathology start-up fund to WZ.
PY - 2008
Y1 - 2008
N2 - In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.
AB - In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.
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U2 - 10.1186/1746-1596-3-6
DO - 10.1186/1746-1596-3-6
M3 - Article
C2 - 18261213
AN - SCOPUS:40749153558
SN - 1746-1596
VL - 3
JO - Diagnostic Pathology
JF - Diagnostic Pathology
IS - 1
M1 - 6
ER -