Endoplasmic reticulum stress activates telomerase

Junzhi Zhou, Beibei Mao, Qi Zhou, Deqiang Ding, Miao Wang, Peng Guo, Yuhao Gao, Jerry W. Shay, Zengqiang Yuan, Yu Sheng Cong

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly, we show that depletion of hTERT sensitizes cells to undergo apoptosis under ER stress, whereas increased hTERT expression reduces ER stress-induced cell death independent of catalytically active enzyme or DNA damage signaling. Our findings establish a functional link between ER stress and telomerase, both of which have important implications in the pathologies associated with aging and cancer.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalAging Cell
Volume13
Issue number1
DOIs
StatePublished - Feb 2014

Fingerprint

Endoplasmic Reticulum Stress
Telomerase
Telomere
DNA Damage
Neoplasms
Cell Survival
Cell Death
Cell Proliferation
Apoptosis
Pathology
Cell Line
Enzymes

Keywords

  • Apoptosis
  • ER stress
  • HTERT
  • Telomerase

ASJC Scopus subject areas

  • Cell Biology
  • Aging
  • Medicine(all)

Cite this

Zhou, J., Mao, B., Zhou, Q., Ding, D., Wang, M., Guo, P., ... Cong, Y. S. (2014). Endoplasmic reticulum stress activates telomerase. Aging Cell, 13(1), 197-200. https://doi.org/10.1111/acel.12161

Endoplasmic reticulum stress activates telomerase. / Zhou, Junzhi; Mao, Beibei; Zhou, Qi; Ding, Deqiang; Wang, Miao; Guo, Peng; Gao, Yuhao; Shay, Jerry W.; Yuan, Zengqiang; Cong, Yu Sheng.

In: Aging Cell, Vol. 13, No. 1, 02.2014, p. 197-200.

Research output: Contribution to journalArticle

Zhou, J, Mao, B, Zhou, Q, Ding, D, Wang, M, Guo, P, Gao, Y, Shay, JW, Yuan, Z & Cong, YS 2014, 'Endoplasmic reticulum stress activates telomerase', Aging Cell, vol. 13, no. 1, pp. 197-200. https://doi.org/10.1111/acel.12161
Zhou J, Mao B, Zhou Q, Ding D, Wang M, Guo P et al. Endoplasmic reticulum stress activates telomerase. Aging Cell. 2014 Feb;13(1):197-200. https://doi.org/10.1111/acel.12161
Zhou, Junzhi ; Mao, Beibei ; Zhou, Qi ; Ding, Deqiang ; Wang, Miao ; Guo, Peng ; Gao, Yuhao ; Shay, Jerry W. ; Yuan, Zengqiang ; Cong, Yu Sheng. / Endoplasmic reticulum stress activates telomerase. In: Aging Cell. 2014 ; Vol. 13, No. 1. pp. 197-200.
@article{648d7e08975f4a53810af11969ae647b,
title = "Endoplasmic reticulum stress activates telomerase",
abstract = "Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly, we show that depletion of hTERT sensitizes cells to undergo apoptosis under ER stress, whereas increased hTERT expression reduces ER stress-induced cell death independent of catalytically active enzyme or DNA damage signaling. Our findings establish a functional link between ER stress and telomerase, both of which have important implications in the pathologies associated with aging and cancer.",
keywords = "Apoptosis, ER stress, HTERT, Telomerase",
author = "Junzhi Zhou and Beibei Mao and Qi Zhou and Deqiang Ding and Miao Wang and Peng Guo and Yuhao Gao and Shay, {Jerry W.} and Zengqiang Yuan and Cong, {Yu Sheng}",
year = "2014",
month = "2",
doi = "10.1111/acel.12161",
language = "English (US)",
volume = "13",
pages = "197--200",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Endoplasmic reticulum stress activates telomerase

AU - Zhou, Junzhi

AU - Mao, Beibei

AU - Zhou, Qi

AU - Ding, Deqiang

AU - Wang, Miao

AU - Guo, Peng

AU - Gao, Yuhao

AU - Shay, Jerry W.

AU - Yuan, Zengqiang

AU - Cong, Yu Sheng

PY - 2014/2

Y1 - 2014/2

N2 - Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly, we show that depletion of hTERT sensitizes cells to undergo apoptosis under ER stress, whereas increased hTERT expression reduces ER stress-induced cell death independent of catalytically active enzyme or DNA damage signaling. Our findings establish a functional link between ER stress and telomerase, both of which have important implications in the pathologies associated with aging and cancer.

AB - Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly, we show that depletion of hTERT sensitizes cells to undergo apoptosis under ER stress, whereas increased hTERT expression reduces ER stress-induced cell death independent of catalytically active enzyme or DNA damage signaling. Our findings establish a functional link between ER stress and telomerase, both of which have important implications in the pathologies associated with aging and cancer.

KW - Apoptosis

KW - ER stress

KW - HTERT

KW - Telomerase

UR - http://www.scopus.com/inward/record.url?scp=84892558088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892558088&partnerID=8YFLogxK

U2 - 10.1111/acel.12161

DO - 10.1111/acel.12161

M3 - Article

C2 - 24119029

AN - SCOPUS:84892558088

VL - 13

SP - 197

EP - 200

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 1

ER -