TY - JOUR
T1 - Endothelin, its diverse biological activities and mechanisms of action
AU - Takuwa, Yoh
AU - Yanagisawa, Masashi
AU - Takuwa, Noriko
AU - Masaki, Tomoh
PY - 1989
Y1 - 1989
N2 - Endothelin, originally identified as a vasoconstrictive peptide derived from vascular endothelial cells, is now known to exert diverse biological effects on a wide variety of tissues and cell types through its own receptor(s). One of the outstanding actions of endothelin is a cell growth promoting activity which is demonstrated in several cell types including cultured vascular smooth muscle cells, fibroblasts, glomerular mesangial cells and osteoblasts. The mitogenic effect is likely mediated by stimulation of phospholipase C via receptor-G-protein coupling, and subsequent activation of protein kinase C. The effect of endothelin may contribute to the cell-proliferation response under various physiological and pathological conditions, such as wound healing and development of atherosclerosis and glomerulonephritis. Recently, three distinct endothelin-related genes have been cloned, suggesting that mammals, including humans, produce three members of this peptide family, endothelin (ET)-1 (the 'classical' endothelin), ET-2 and ET-3, which may act on distinct subtypes of endothelin receptor to induce different cellular responses.
AB - Endothelin, originally identified as a vasoconstrictive peptide derived from vascular endothelial cells, is now known to exert diverse biological effects on a wide variety of tissues and cell types through its own receptor(s). One of the outstanding actions of endothelin is a cell growth promoting activity which is demonstrated in several cell types including cultured vascular smooth muscle cells, fibroblasts, glomerular mesangial cells and osteoblasts. The mitogenic effect is likely mediated by stimulation of phospholipase C via receptor-G-protein coupling, and subsequent activation of protein kinase C. The effect of endothelin may contribute to the cell-proliferation response under various physiological and pathological conditions, such as wound healing and development of atherosclerosis and glomerulonephritis. Recently, three distinct endothelin-related genes have been cloned, suggesting that mammals, including humans, produce three members of this peptide family, endothelin (ET)-1 (the 'classical' endothelin), ET-2 and ET-3, which may act on distinct subtypes of endothelin receptor to induce different cellular responses.
KW - Ca channel
KW - Endothelin
KW - G-protein
KW - growth factor
KW - phospholipase C
KW - vasoconstrictor
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U2 - 10.1016/0955-2235(89)90011-2
DO - 10.1016/0955-2235(89)90011-2
M3 - Article
C2 - 2491262
AN - SCOPUS:0024933239
SN - 0955-2235
VL - 1
SP - 195
EP - 206
JO - Progress in Growth Factor Research
JF - Progress in Growth Factor Research
IS - 4
ER -