Energy expenditure in obesity associated with craniopharyngioma

Roy J. Kim, Rachana Shah, Andy M. Tershakovec, Babette S. Zemel, Leslie N. Sutton, Adda Grimberg, Thomas Moshang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background and purpose Obesity is a common yet incompletely understood complication of childhood craniopharyngioma. We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children. Methods Eleven craniopharyngioma patients were recruited for a study on body composition and energy balance. Eight subjects were obese. The obese craniopharyngioma patients had a mean age (±SD) of 11.2±1.7 years. The average bodymass index z score was 2.33 (±0.32). A previously studied group of obese children (BMI z score 2.46±0.46) served as controls. Resting energy expenditure (REE) was determined by indirect calorimetry and body composition by dual energy X-ray absorptiometry in all children. Results Obese craniopharyngioma patient subjects had increased mean (±standard error) fat-free mass compared to obese controls (57%±0.88 % vs 50.0%±0.87%, p=0.02). The obese craniopharyngioma patients had a 17% lower REE compared to values expected from the World Health Organization equation (1,541±112.6 vs 1,809±151.8 kcal; p=0.01). In contrast, the obese control children had measured REE within 1% of predicted (1,647±33.2 vs. 1,652±40.2; p=0.8). In a linear regression model, REE remained significantly lower than predicted after controlling for FFM. Conclusions Lower REE may be a factor contributing to obesity in children with craniopharyngioma. Further study is needed into the mechanisms for reduced energy expenditure in patients with craniopharyngioma.

Original languageEnglish (US)
Pages (from-to)913-917
Number of pages5
JournalChild's Nervous System
Volume26
Issue number7
DOIs
StatePublished - Jul 2010

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Craniopharyngioma
Energy Metabolism
Obesity
Body Composition
Linear Models
Indirect Calorimetry
Photon Absorptiometry
Fats

Keywords

  • Craniopharyngioma
  • Energy expenditure
  • Hypothalamic obesity
  • Obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Kim, R. J., Shah, R., Tershakovec, A. M., Zemel, B. S., Sutton, L. N., Grimberg, A., & Moshang, T. (2010). Energy expenditure in obesity associated with craniopharyngioma. Child's Nervous System, 26(7), 913-917. https://doi.org/10.1007/s00381-009-1078-1

Energy expenditure in obesity associated with craniopharyngioma. / Kim, Roy J.; Shah, Rachana; Tershakovec, Andy M.; Zemel, Babette S.; Sutton, Leslie N.; Grimberg, Adda; Moshang, Thomas.

In: Child's Nervous System, Vol. 26, No. 7, 07.2010, p. 913-917.

Research output: Contribution to journalArticle

Kim, RJ, Shah, R, Tershakovec, AM, Zemel, BS, Sutton, LN, Grimberg, A & Moshang, T 2010, 'Energy expenditure in obesity associated with craniopharyngioma', Child's Nervous System, vol. 26, no. 7, pp. 913-917. https://doi.org/10.1007/s00381-009-1078-1
Kim RJ, Shah R, Tershakovec AM, Zemel BS, Sutton LN, Grimberg A et al. Energy expenditure in obesity associated with craniopharyngioma. Child's Nervous System. 2010 Jul;26(7):913-917. https://doi.org/10.1007/s00381-009-1078-1
Kim, Roy J. ; Shah, Rachana ; Tershakovec, Andy M. ; Zemel, Babette S. ; Sutton, Leslie N. ; Grimberg, Adda ; Moshang, Thomas. / Energy expenditure in obesity associated with craniopharyngioma. In: Child's Nervous System. 2010 ; Vol. 26, No. 7. pp. 913-917.
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abstract = "Background and purpose Obesity is a common yet incompletely understood complication of childhood craniopharyngioma. We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children. Methods Eleven craniopharyngioma patients were recruited for a study on body composition and energy balance. Eight subjects were obese. The obese craniopharyngioma patients had a mean age (±SD) of 11.2±1.7 years. The average bodymass index z score was 2.33 (±0.32). A previously studied group of obese children (BMI z score 2.46±0.46) served as controls. Resting energy expenditure (REE) was determined by indirect calorimetry and body composition by dual energy X-ray absorptiometry in all children. Results Obese craniopharyngioma patient subjects had increased mean (±standard error) fat-free mass compared to obese controls (57{\%}±0.88 {\%} vs 50.0{\%}±0.87{\%}, p=0.02). The obese craniopharyngioma patients had a 17{\%} lower REE compared to values expected from the World Health Organization equation (1,541±112.6 vs 1,809±151.8 kcal; p=0.01). In contrast, the obese control children had measured REE within 1{\%} of predicted (1,647±33.2 vs. 1,652±40.2; p=0.8). In a linear regression model, REE remained significantly lower than predicted after controlling for FFM. Conclusions Lower REE may be a factor contributing to obesity in children with craniopharyngioma. Further study is needed into the mechanisms for reduced energy expenditure in patients with craniopharyngioma.",
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AB - Background and purpose Obesity is a common yet incompletely understood complication of childhood craniopharyngioma. We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children. Methods Eleven craniopharyngioma patients were recruited for a study on body composition and energy balance. Eight subjects were obese. The obese craniopharyngioma patients had a mean age (±SD) of 11.2±1.7 years. The average bodymass index z score was 2.33 (±0.32). A previously studied group of obese children (BMI z score 2.46±0.46) served as controls. Resting energy expenditure (REE) was determined by indirect calorimetry and body composition by dual energy X-ray absorptiometry in all children. Results Obese craniopharyngioma patient subjects had increased mean (±standard error) fat-free mass compared to obese controls (57%±0.88 % vs 50.0%±0.87%, p=0.02). The obese craniopharyngioma patients had a 17% lower REE compared to values expected from the World Health Organization equation (1,541±112.6 vs 1,809±151.8 kcal; p=0.01). In contrast, the obese control children had measured REE within 1% of predicted (1,647±33.2 vs. 1,652±40.2; p=0.8). In a linear regression model, REE remained significantly lower than predicted after controlling for FFM. Conclusions Lower REE may be a factor contributing to obesity in children with craniopharyngioma. Further study is needed into the mechanisms for reduced energy expenditure in patients with craniopharyngioma.

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