Enhanced hybridization by peptide nucleic acids

David R. Corey, Susan Hamilton, Carla Simmons, Lynn Mayfield, Anne Pitts

Research output: Contribution to journalArticle

Abstract

Peptide nucleic acids (PNAs) are DNA analogs containing neutral amide backbone linkages. PNAs are stable to degradation by enzymes and hybridize to complementary sequences with higher affinity than analogous DNA otigomers. PNA synthesis employs protocols derived from solid-phase peptide synthesis, making the methodology straightforward and flexible, PNAs are being incorporated into an expanding set of applications, including genome mapping, identification of mutations, and evaluation of telomere length. The growth in the popularity of PNAs as a motif for nucleic acid recognition should accelerate as properties of PNAs become more familiar.

Original languageEnglish (US)
Number of pages1
JournalFibrinolysis and Proteolysis
Volume11
Issue numberSUPPL. 3
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Hematology

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    Corey, D. R., Hamilton, S., Simmons, C., Mayfield, L., & Pitts, A. (1997). Enhanced hybridization by peptide nucleic acids. Fibrinolysis and Proteolysis, 11(SUPPL. 3).