The mammalian gastrointestinal (GI) tract harbors a diverse collection of indigenous bacteria known as the microbiota. The number of bacterial cells within our bodies exceeds the number of our cells by one order of magnitude (3). Homeostasis of the microbiota is maintained by differential nutrient utilization and physical separation from the gut mucosa (4). However, environmental perturbations such as antibiotic treatment, changes in diet, and infection lead to substantial alterations in composition and structure of the microbiota, referred to as dysbiosis (5 - 8).
- Enteric pathogen
- Gut microbiota
- Locus of enterocyte effacement
- Stratified mucus layer
ASJC Scopus subject areas
- Immunology and Microbiology(all)