TY - JOUR
T1 - Environmental exposure to dioxins, dibenzofurans, bisphenol a, and phthalates in children with and without autism spectrum disorder living near the gulf of Mexico
AU - Rahbar, Mohammad H.
AU - Swingle, Hanes M.
AU - Christian, Mackinsey A.
AU - Hessabi, Manouchehr
AU - Lee, Minjae
AU - Pitcher, Meagan R.
AU - Campbell, Sean
AU - Mitchell, Amy
AU - Krone, Ryan
AU - Loveland, Katherine A.
AU - Patterson, Donald G.
N1 - Funding Information:
Acknowledgments: This pilot research project is funded by the University of Texas Health Science Center at Houston. We also acknowledge the support provided by the Biostatistics/Epidemiology/Research Design (BERD) component of the Center for Clinical and Translational Sciences (CCTS) for this project. CCTS is partly funded by grant UL1 TR000371 from the National Center for Advancing Translational Sciences (NCATS), awarded to University of Texas Health Science Center at Houston. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NCATS. Furthermore, we acknowledge that the collection and management of survey data were done using REDCap [63].
PY - 2017/11/21
Y1 - 2017/11/21
N2 - Environmental exposure to organic endocrine disrupting chemicals, including dioxins, dibenzofurans, bisphenol A (BPA), and phthalates has been associated with neurodevelopmental disorders, including autism spectrum disorder (ASD). We conducted a pilot monitoring study of 30 ASD cases and 10 typically developing (TD) controls ages 2-8 years from communities along the Gulf of Mexico near Alabama, which houses 14 Superfund sites, to assess the concentrations of dioxins and dibenzofurans in serum, and BPA and phthalate ester metabolites in urine. Based on General Linear Models, the lipid- or creatinine-adjusted geometric mean concentrations of the aforementioned chemicals did not differ between the ASD case and TD control groups (all p ≥ 0.27). We compared our findings to the adjusted means as reported by the National Health and Nutrition Examination Survey, survey years 2011-2012, and found that TD controls in our study had lower BPA (59%) and MEHHP (26%) concentrations, higher MBP (50%) concentration, and comparable (<20% difference) MEP, MBZP, MEOHP, and MCPP concentrations. We also conducted a preliminary investigation of dietary exposures and found that the consumption of certain types of fish may be associated with higher OCDD concentrations, and the consumption of soft drinks and juices may be associated with lower BPA and MEOHP concentrations, respectively.
AB - Environmental exposure to organic endocrine disrupting chemicals, including dioxins, dibenzofurans, bisphenol A (BPA), and phthalates has been associated with neurodevelopmental disorders, including autism spectrum disorder (ASD). We conducted a pilot monitoring study of 30 ASD cases and 10 typically developing (TD) controls ages 2-8 years from communities along the Gulf of Mexico near Alabama, which houses 14 Superfund sites, to assess the concentrations of dioxins and dibenzofurans in serum, and BPA and phthalate ester metabolites in urine. Based on General Linear Models, the lipid- or creatinine-adjusted geometric mean concentrations of the aforementioned chemicals did not differ between the ASD case and TD control groups (all p ≥ 0.27). We compared our findings to the adjusted means as reported by the National Health and Nutrition Examination Survey, survey years 2011-2012, and found that TD controls in our study had lower BPA (59%) and MEHHP (26%) concentrations, higher MBP (50%) concentration, and comparable (<20% difference) MEP, MBZP, MEOHP, and MCPP concentrations. We also conducted a preliminary investigation of dietary exposures and found that the consumption of certain types of fish may be associated with higher OCDD concentrations, and the consumption of soft drinks and juices may be associated with lower BPA and MEOHP concentrations, respectively.
KW - Bisphenol A
KW - Children
KW - Dibenzofurans
KW - Dioxins
KW - Gulf of Mexico
KW - Neurodevelopmental disorder
KW - Phthalates
KW - Rautism spectrum disorder (ASD)
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U2 - 10.3390/ijerph14111425
DO - 10.3390/ijerph14111425
M3 - Article
C2 - 29160842
AN - SCOPUS:85035072595
VL - 14
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 11
M1 - 1425
ER -