EphB signaling controls lineage plasticity of adult neural stem cell niche cells

Tadashi Nomura, Christian Göritz, Timothy Catchpole, Mark Henkemeyer, Jonas Frisén

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Stem cells remain in specialized niches over the lifespan of the organism in many organs to ensure tissue homeostasis and enable regeneration. How the niche is maintained is not understood, but is probably as important as intrinsic stem cell self-renewal capacity for tissue integrity. We here demonstrate a high degree of phenotypic plasticity of the two main niche cell types, ependymal cells and astrocytes, in the neurogenic lateral ventricle walls in the adult mouse brain. In response to a lesion, astrocytes give rise to ependymal cells and ependymal cells give rise to niche astrocytes. We identify EphB2 forward signaling as a key pathway regulating niche cell plasticity. EphB2 acts downstream of Notch and is required for the maintenance of ependymal cell characteristics, thereby inhibiting the transition from ependymal cell to astrocyte. Our results show that niche cell identity is actively maintained and that niche cells retain a high level of plasticity.

Original languageEnglish (US)
Pages (from-to)730-743
Number of pages14
JournalCell Stem Cell
Volume7
Issue number6
DOIs
StatePublished - Dec 3 2010

Fingerprint

Stem Cell Niche
Adult Stem Cells
Neural Stem Cells
Astrocytes
Lateral Ventricles
Regeneration
Homeostasis
Stem Cells
Maintenance
Brain

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

Cite this

EphB signaling controls lineage plasticity of adult neural stem cell niche cells. / Nomura, Tadashi; Göritz, Christian; Catchpole, Timothy; Henkemeyer, Mark; Frisén, Jonas.

In: Cell Stem Cell, Vol. 7, No. 6, 03.12.2010, p. 730-743.

Research output: Contribution to journalArticle

Nomura, Tadashi ; Göritz, Christian ; Catchpole, Timothy ; Henkemeyer, Mark ; Frisén, Jonas. / EphB signaling controls lineage plasticity of adult neural stem cell niche cells. In: Cell Stem Cell. 2010 ; Vol. 7, No. 6. pp. 730-743.
@article{dcb374f60da742f6bde212318a9de0b7,
title = "EphB signaling controls lineage plasticity of adult neural stem cell niche cells",
abstract = "Stem cells remain in specialized niches over the lifespan of the organism in many organs to ensure tissue homeostasis and enable regeneration. How the niche is maintained is not understood, but is probably as important as intrinsic stem cell self-renewal capacity for tissue integrity. We here demonstrate a high degree of phenotypic plasticity of the two main niche cell types, ependymal cells and astrocytes, in the neurogenic lateral ventricle walls in the adult mouse brain. In response to a lesion, astrocytes give rise to ependymal cells and ependymal cells give rise to niche astrocytes. We identify EphB2 forward signaling as a key pathway regulating niche cell plasticity. EphB2 acts downstream of Notch and is required for the maintenance of ependymal cell characteristics, thereby inhibiting the transition from ependymal cell to astrocyte. Our results show that niche cell identity is actively maintained and that niche cells retain a high level of plasticity.",
author = "Tadashi Nomura and Christian G{\"o}ritz and Timothy Catchpole and Mark Henkemeyer and Jonas Fris{\'e}n",
year = "2010",
month = "12",
day = "3",
doi = "10.1016/j.stem.2010.11.009",
language = "English (US)",
volume = "7",
pages = "730--743",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - EphB signaling controls lineage plasticity of adult neural stem cell niche cells

AU - Nomura, Tadashi

AU - Göritz, Christian

AU - Catchpole, Timothy

AU - Henkemeyer, Mark

AU - Frisén, Jonas

PY - 2010/12/3

Y1 - 2010/12/3

N2 - Stem cells remain in specialized niches over the lifespan of the organism in many organs to ensure tissue homeostasis and enable regeneration. How the niche is maintained is not understood, but is probably as important as intrinsic stem cell self-renewal capacity for tissue integrity. We here demonstrate a high degree of phenotypic plasticity of the two main niche cell types, ependymal cells and astrocytes, in the neurogenic lateral ventricle walls in the adult mouse brain. In response to a lesion, astrocytes give rise to ependymal cells and ependymal cells give rise to niche astrocytes. We identify EphB2 forward signaling as a key pathway regulating niche cell plasticity. EphB2 acts downstream of Notch and is required for the maintenance of ependymal cell characteristics, thereby inhibiting the transition from ependymal cell to astrocyte. Our results show that niche cell identity is actively maintained and that niche cells retain a high level of plasticity.

AB - Stem cells remain in specialized niches over the lifespan of the organism in many organs to ensure tissue homeostasis and enable regeneration. How the niche is maintained is not understood, but is probably as important as intrinsic stem cell self-renewal capacity for tissue integrity. We here demonstrate a high degree of phenotypic plasticity of the two main niche cell types, ependymal cells and astrocytes, in the neurogenic lateral ventricle walls in the adult mouse brain. In response to a lesion, astrocytes give rise to ependymal cells and ependymal cells give rise to niche astrocytes. We identify EphB2 forward signaling as a key pathway regulating niche cell plasticity. EphB2 acts downstream of Notch and is required for the maintenance of ependymal cell characteristics, thereby inhibiting the transition from ependymal cell to astrocyte. Our results show that niche cell identity is actively maintained and that niche cells retain a high level of plasticity.

UR - http://www.scopus.com/inward/record.url?scp=78649667896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649667896&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2010.11.009

DO - 10.1016/j.stem.2010.11.009

M3 - Article

VL - 7

SP - 730

EP - 743

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 6

ER -