Epicardial prestrained confinement and residual stresses

a newly observed heart ventricle confinement interface

Xiaodan Shi, Yue Liu, Katherine M. Copeland, Sara R. McMahan, Song Zhang, J. Ryan Butler, Yi Hong, Michael Cho, Pietro Bajona, Huajian Gao, Jun Liao

Research output: Contribution to journalArticle

Abstract

The heart epicardial layer, with elastin as the dominant component, has not been well investigated, specifically on how it contributes to ventricular biomechanics. In this study, we revealed and quantitatively assessed the overall status of prestraining and residual stresses exerted by the epicardial layer on the heart left ventricle (LV). During porcine heart wall dissection, we discovered that bi-layered LV surface strips, consisting of an epicardial layer and cardiac muscle, always curled towards the epicardial side due to epicardial residual stresses. We hence developed a curling angle characterization technique to intuitively and qualitatively reveal the location-dependency and direction-dependency of epicardial residual stresses. Moreover, by combining prestrain measurement and biaxial mechanical testing, we were able to quantify the epicardial prestrains and residual stresses on the unpressurized intact LV. To investigate the potential mechanical effect of epicardial prestraining, a finite-element (FE) model has been constructed, and we demonstrate that it is the prestraining of the epicardial layer, not the epicardial layer alone, providing an additional resistance mechanism during LV diastolic expansion and ventricular wall protection by reducing myocardial stress. In short, our study on healthy, native porcine hearts has revealed an important phenomenon-the epicardial layer, rich in elastin, acts like a prestrained 'balloon' that wraps around the heart and functions as an extra confinement and protection interface. The obtained knowledge fills a gap in ventricular biomechanics and will help design novel biomimicking materials or prosthetic devices to target the maintenance/recreation of this ventricle confinement interface.

Original languageEnglish (US)
Number of pages1
JournalJournal of the Royal Society, Interface
Volume16
Issue number152
DOIs
StatePublished - Mar 29 2019

Fingerprint

Heart Ventricles
Residual stresses
Elastin
Biomechanics
Biomechanical Phenomena
Swine
Dissection
Recreation
Mechanical testing
Balloons
Prosthetics
Muscle
Myocardium
Maintenance
Equipment and Supplies

Keywords

  • cardiac elastin
  • epicardial layer
  • epicardial prestraining
  • epicardial residual stress
  • heart
  • ventricle confinement interface

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

Cite this

Epicardial prestrained confinement and residual stresses : a newly observed heart ventricle confinement interface. / Shi, Xiaodan; Liu, Yue; Copeland, Katherine M.; McMahan, Sara R.; Zhang, Song; Butler, J. Ryan; Hong, Yi; Cho, Michael; Bajona, Pietro; Gao, Huajian; Liao, Jun.

In: Journal of the Royal Society, Interface, Vol. 16, No. 152, 29.03.2019.

Research output: Contribution to journalArticle

Shi, Xiaodan ; Liu, Yue ; Copeland, Katherine M. ; McMahan, Sara R. ; Zhang, Song ; Butler, J. Ryan ; Hong, Yi ; Cho, Michael ; Bajona, Pietro ; Gao, Huajian ; Liao, Jun. / Epicardial prestrained confinement and residual stresses : a newly observed heart ventricle confinement interface. In: Journal of the Royal Society, Interface. 2019 ; Vol. 16, No. 152.
@article{05711f9725a84a039f808518411d1ec7,
title = "Epicardial prestrained confinement and residual stresses: a newly observed heart ventricle confinement interface",
abstract = "The heart epicardial layer, with elastin as the dominant component, has not been well investigated, specifically on how it contributes to ventricular biomechanics. In this study, we revealed and quantitatively assessed the overall status of prestraining and residual stresses exerted by the epicardial layer on the heart left ventricle (LV). During porcine heart wall dissection, we discovered that bi-layered LV surface strips, consisting of an epicardial layer and cardiac muscle, always curled towards the epicardial side due to epicardial residual stresses. We hence developed a curling angle characterization technique to intuitively and qualitatively reveal the location-dependency and direction-dependency of epicardial residual stresses. Moreover, by combining prestrain measurement and biaxial mechanical testing, we were able to quantify the epicardial prestrains and residual stresses on the unpressurized intact LV. To investigate the potential mechanical effect of epicardial prestraining, a finite-element (FE) model has been constructed, and we demonstrate that it is the prestraining of the epicardial layer, not the epicardial layer alone, providing an additional resistance mechanism during LV diastolic expansion and ventricular wall protection by reducing myocardial stress. In short, our study on healthy, native porcine hearts has revealed an important phenomenon-the epicardial layer, rich in elastin, acts like a prestrained 'balloon' that wraps around the heart and functions as an extra confinement and protection interface. The obtained knowledge fills a gap in ventricular biomechanics and will help design novel biomimicking materials or prosthetic devices to target the maintenance/recreation of this ventricle confinement interface.",
keywords = "cardiac elastin, epicardial layer, epicardial prestraining, epicardial residual stress, heart, ventricle confinement interface",
author = "Xiaodan Shi and Yue Liu and Copeland, {Katherine M.} and McMahan, {Sara R.} and Song Zhang and Butler, {J. Ryan} and Yi Hong and Michael Cho and Pietro Bajona and Huajian Gao and Jun Liao",
year = "2019",
month = "3",
day = "29",
doi = "10.1098/rsif.2019.0028",
language = "English (US)",
volume = "16",
journal = "Journal of the Royal Society Interface",
issn = "1742-5689",
publisher = "Royal Society of London",
number = "152",

}

TY - JOUR

T1 - Epicardial prestrained confinement and residual stresses

T2 - a newly observed heart ventricle confinement interface

AU - Shi, Xiaodan

AU - Liu, Yue

AU - Copeland, Katherine M.

AU - McMahan, Sara R.

AU - Zhang, Song

AU - Butler, J. Ryan

AU - Hong, Yi

AU - Cho, Michael

AU - Bajona, Pietro

AU - Gao, Huajian

AU - Liao, Jun

PY - 2019/3/29

Y1 - 2019/3/29

N2 - The heart epicardial layer, with elastin as the dominant component, has not been well investigated, specifically on how it contributes to ventricular biomechanics. In this study, we revealed and quantitatively assessed the overall status of prestraining and residual stresses exerted by the epicardial layer on the heart left ventricle (LV). During porcine heart wall dissection, we discovered that bi-layered LV surface strips, consisting of an epicardial layer and cardiac muscle, always curled towards the epicardial side due to epicardial residual stresses. We hence developed a curling angle characterization technique to intuitively and qualitatively reveal the location-dependency and direction-dependency of epicardial residual stresses. Moreover, by combining prestrain measurement and biaxial mechanical testing, we were able to quantify the epicardial prestrains and residual stresses on the unpressurized intact LV. To investigate the potential mechanical effect of epicardial prestraining, a finite-element (FE) model has been constructed, and we demonstrate that it is the prestraining of the epicardial layer, not the epicardial layer alone, providing an additional resistance mechanism during LV diastolic expansion and ventricular wall protection by reducing myocardial stress. In short, our study on healthy, native porcine hearts has revealed an important phenomenon-the epicardial layer, rich in elastin, acts like a prestrained 'balloon' that wraps around the heart and functions as an extra confinement and protection interface. The obtained knowledge fills a gap in ventricular biomechanics and will help design novel biomimicking materials or prosthetic devices to target the maintenance/recreation of this ventricle confinement interface.

AB - The heart epicardial layer, with elastin as the dominant component, has not been well investigated, specifically on how it contributes to ventricular biomechanics. In this study, we revealed and quantitatively assessed the overall status of prestraining and residual stresses exerted by the epicardial layer on the heart left ventricle (LV). During porcine heart wall dissection, we discovered that bi-layered LV surface strips, consisting of an epicardial layer and cardiac muscle, always curled towards the epicardial side due to epicardial residual stresses. We hence developed a curling angle characterization technique to intuitively and qualitatively reveal the location-dependency and direction-dependency of epicardial residual stresses. Moreover, by combining prestrain measurement and biaxial mechanical testing, we were able to quantify the epicardial prestrains and residual stresses on the unpressurized intact LV. To investigate the potential mechanical effect of epicardial prestraining, a finite-element (FE) model has been constructed, and we demonstrate that it is the prestraining of the epicardial layer, not the epicardial layer alone, providing an additional resistance mechanism during LV diastolic expansion and ventricular wall protection by reducing myocardial stress. In short, our study on healthy, native porcine hearts has revealed an important phenomenon-the epicardial layer, rich in elastin, acts like a prestrained 'balloon' that wraps around the heart and functions as an extra confinement and protection interface. The obtained knowledge fills a gap in ventricular biomechanics and will help design novel biomimicking materials or prosthetic devices to target the maintenance/recreation of this ventricle confinement interface.

KW - cardiac elastin

KW - epicardial layer

KW - epicardial prestraining

KW - epicardial residual stress

KW - heart

KW - ventricle confinement interface

UR - http://www.scopus.com/inward/record.url?scp=85062879439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062879439&partnerID=8YFLogxK

U2 - 10.1098/rsif.2019.0028

DO - 10.1098/rsif.2019.0028

M3 - Article

VL - 16

JO - Journal of the Royal Society Interface

JF - Journal of the Royal Society Interface

SN - 1742-5689

IS - 152

ER -