Epidemiologic features and clinical subgroups of anotia/microtia in Texas

Mark A. Canfield, Peter H. Langlois, Ly M. Nguyen, Angela E. Scheuerle

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

BACKGROUND: Few studies have investigated the epidemiologic features of clinically defined subgroups of anotia/microtia. METHODS: Data on cases of anotia and/or microtia among 1999-2005 deliveries were obtained from the Texas Birth Defects Registry, a population-based active surveillance system. We determined crude and adjusted associations between selected factors and seven clinical subgroups of anotia/ microtia. RESULTS: In total, 742 cases were diagnosed with anotia and/or microtia, corresponding to a prevalence of 2.86 per 10,000 live births. Of those, 45% had no other major birth defect ("isolated"), 77% were unilateral, and 22% bilateral. Anotia alone made up 6%, whereas microtia made up 94%. Birth prevalence was higher with increasing maternal age and among Mexico-born Hispanics. Compared to white mothers, Hispanic mothers were two-to-three times more likely to have infants with all but the syndromic and bilateral groups (adjusted prevalence ratios [aPRs] = 2.05-2.61). Non-Hispanic blacks had significantly lower risk for total anotia/microtia, and for the isolated, unilateral, and microtia subgroups (aPRs = 0.42-0.64). Less educated mothers were three-to-four times more likely to have children with anotia (aPRs = 2.98 for less than high school, 3.97 for high school graduates). Males were more likely to be born with total anotia/microtia and with syndromic, unilateral, and microtia subtypes (aPRs = 1.27-1.41). CONCLUSIONS: In Texas, most anotia/microtia cases were in the unilateral and microtia groups, and 45% were isolated. Several clinical subgroups exhibited higher prevalence in males and among older mothers. Relative to whites, blacks were at lower risk and Hispanics (especially Mexico-born mothers) were at higher risk for selected types of anotia/microtia.

Original languageEnglish (US)
Pages (from-to)905-913
Number of pages9
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume85
Issue number11
DOIs
StatePublished - Nov 2009

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Mothers
Hispanic Americans
Mexico
Microtia-Anotia
Maternal Age
Live Birth
Registries
Congenital Microtia
Parturition
Population

Keywords

  • Anotia
  • Birth defect
  • Ear
  • Epidemiology
  • Microtia
  • Prevalence
  • Risk factor
  • Texas

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health
  • Embryology

Cite this

Epidemiologic features and clinical subgroups of anotia/microtia in Texas. / Canfield, Mark A.; Langlois, Peter H.; Nguyen, Ly M.; Scheuerle, Angela E.

In: Birth Defects Research Part A - Clinical and Molecular Teratology, Vol. 85, No. 11, 11.2009, p. 905-913.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND: Few studies have investigated the epidemiologic features of clinically defined subgroups of anotia/microtia. METHODS: Data on cases of anotia and/or microtia among 1999-2005 deliveries were obtained from the Texas Birth Defects Registry, a population-based active surveillance system. We determined crude and adjusted associations between selected factors and seven clinical subgroups of anotia/ microtia. RESULTS: In total, 742 cases were diagnosed with anotia and/or microtia, corresponding to a prevalence of 2.86 per 10,000 live births. Of those, 45{\%} had no other major birth defect ({"}isolated{"}), 77{\%} were unilateral, and 22{\%} bilateral. Anotia alone made up 6{\%}, whereas microtia made up 94{\%}. Birth prevalence was higher with increasing maternal age and among Mexico-born Hispanics. Compared to white mothers, Hispanic mothers were two-to-three times more likely to have infants with all but the syndromic and bilateral groups (adjusted prevalence ratios [aPRs] = 2.05-2.61). Non-Hispanic blacks had significantly lower risk for total anotia/microtia, and for the isolated, unilateral, and microtia subgroups (aPRs = 0.42-0.64). Less educated mothers were three-to-four times more likely to have children with anotia (aPRs = 2.98 for less than high school, 3.97 for high school graduates). Males were more likely to be born with total anotia/microtia and with syndromic, unilateral, and microtia subtypes (aPRs = 1.27-1.41). CONCLUSIONS: In Texas, most anotia/microtia cases were in the unilateral and microtia groups, and 45{\%} were isolated. Several clinical subgroups exhibited higher prevalence in males and among older mothers. Relative to whites, blacks were at lower risk and Hispanics (especially Mexico-born mothers) were at higher risk for selected types of anotia/microtia.",
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AU - Canfield, Mark A.

AU - Langlois, Peter H.

AU - Nguyen, Ly M.

AU - Scheuerle, Angela E.

PY - 2009/11

Y1 - 2009/11

N2 - BACKGROUND: Few studies have investigated the epidemiologic features of clinically defined subgroups of anotia/microtia. METHODS: Data on cases of anotia and/or microtia among 1999-2005 deliveries were obtained from the Texas Birth Defects Registry, a population-based active surveillance system. We determined crude and adjusted associations between selected factors and seven clinical subgroups of anotia/ microtia. RESULTS: In total, 742 cases were diagnosed with anotia and/or microtia, corresponding to a prevalence of 2.86 per 10,000 live births. Of those, 45% had no other major birth defect ("isolated"), 77% were unilateral, and 22% bilateral. Anotia alone made up 6%, whereas microtia made up 94%. Birth prevalence was higher with increasing maternal age and among Mexico-born Hispanics. Compared to white mothers, Hispanic mothers were two-to-three times more likely to have infants with all but the syndromic and bilateral groups (adjusted prevalence ratios [aPRs] = 2.05-2.61). Non-Hispanic blacks had significantly lower risk for total anotia/microtia, and for the isolated, unilateral, and microtia subgroups (aPRs = 0.42-0.64). Less educated mothers were three-to-four times more likely to have children with anotia (aPRs = 2.98 for less than high school, 3.97 for high school graduates). Males were more likely to be born with total anotia/microtia and with syndromic, unilateral, and microtia subtypes (aPRs = 1.27-1.41). CONCLUSIONS: In Texas, most anotia/microtia cases were in the unilateral and microtia groups, and 45% were isolated. Several clinical subgroups exhibited higher prevalence in males and among older mothers. Relative to whites, blacks were at lower risk and Hispanics (especially Mexico-born mothers) were at higher risk for selected types of anotia/microtia.

AB - BACKGROUND: Few studies have investigated the epidemiologic features of clinically defined subgroups of anotia/microtia. METHODS: Data on cases of anotia and/or microtia among 1999-2005 deliveries were obtained from the Texas Birth Defects Registry, a population-based active surveillance system. We determined crude and adjusted associations between selected factors and seven clinical subgroups of anotia/ microtia. RESULTS: In total, 742 cases were diagnosed with anotia and/or microtia, corresponding to a prevalence of 2.86 per 10,000 live births. Of those, 45% had no other major birth defect ("isolated"), 77% were unilateral, and 22% bilateral. Anotia alone made up 6%, whereas microtia made up 94%. Birth prevalence was higher with increasing maternal age and among Mexico-born Hispanics. Compared to white mothers, Hispanic mothers were two-to-three times more likely to have infants with all but the syndromic and bilateral groups (adjusted prevalence ratios [aPRs] = 2.05-2.61). Non-Hispanic blacks had significantly lower risk for total anotia/microtia, and for the isolated, unilateral, and microtia subgroups (aPRs = 0.42-0.64). Less educated mothers were three-to-four times more likely to have children with anotia (aPRs = 2.98 for less than high school, 3.97 for high school graduates). Males were more likely to be born with total anotia/microtia and with syndromic, unilateral, and microtia subtypes (aPRs = 1.27-1.41). CONCLUSIONS: In Texas, most anotia/microtia cases were in the unilateral and microtia groups, and 45% were isolated. Several clinical subgroups exhibited higher prevalence in males and among older mothers. Relative to whites, blacks were at lower risk and Hispanics (especially Mexico-born mothers) were at higher risk for selected types of anotia/microtia.

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KW - Birth defect

KW - Ear

KW - Epidemiology

KW - Microtia

KW - Prevalence

KW - Risk factor

KW - Texas

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