TY - JOUR
T1 - Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders
T2 - Unraveling the genome to understand the mind
AU - Hsieh, Jenny
AU - Eisch, Amelia J
N1 - Funding Information:
We apologize to the many researchers whose work was not cited in this review due to space limitations. We thank Jiang Wu for critical reading of the manuscript and Jose Cabrera for graphics. Work in the laboratory of JH is supported by grants from the NIH, the Ellison Medical Foundation, the Welch Foundation, and the Citizens United for Research in Epilepsy. Work in the laboratory of AJE is supported by grants from the NIH, the National Institute on Drug Abuse, and NASA.
PY - 2010/7
Y1 - 2010/7
N2 - In mature, differentiated neurons in the central nervous system (CNS), epigenetic mechanisms-including DNA methylation, histone modification, and regulatory noncoding RNAs-play critical roles in encoding experience and environmental stimuli into stable, behaviorally meaningful changes in gene expression. For example, epigenetic changes in mature hippocampal neurons have been implicated in learning and memory and in a variety of neuropsychiatric disorders, including depression. With all the recent (and warranted) attention given to epigenetic modifications in mature neurons, it is easy to forget that epigenetic mechanisms were initially described for their ability to promote differentiation and drive cell fate in embryonic and early postnatal development, including neurogenesis. Given the discovery of ongoing neurogenesis in the adult brain and the intriguing links among adult hippocampal neurogenesis, hippocampal function, and neuropsychiatric disorders, it is timely to complement the ongoing discussions on the role of epigenetics in mature neurons with a review on what is currently known about the role of epigenetics in adult hippocampal neurogenesis. The process of adult hippocampal neurogenesis is complex, with neural stem cells (NSCs) giving rise to fate-restricted progenitors and eventually mature dentate gyrus granule cells. Notably, neurogenesis occurs within an increasingly well-defined "neurogenic niche", where mature cellular elements like vasculature, astrocytes, and neurons release signals that can dynamically regulate neurogenesis. Here we review the evidence that key stages and aspects of adult neurogenesis are driven by epigenetic mechanisms. We discuss the intrinsic changes occurring within NSCs and their progeny that are critical for neurogenesis. We also discuss how extrinsic changes occurring in cellular components in the niche can result in altered neurogenesis. Finally we describe the potential relevance of epigenetics for understanding the relationship between hippocampal neurogenesis in neuropsychiatric disorders. We propose that a more thorough understanding of the molecular and genetic mechanisms that control the complex process of neurogenesis, including the proliferation and differentiation of NSCs, will lead to novel therapeutics for the treatment of neuropsychiatric disorders.
AB - In mature, differentiated neurons in the central nervous system (CNS), epigenetic mechanisms-including DNA methylation, histone modification, and regulatory noncoding RNAs-play critical roles in encoding experience and environmental stimuli into stable, behaviorally meaningful changes in gene expression. For example, epigenetic changes in mature hippocampal neurons have been implicated in learning and memory and in a variety of neuropsychiatric disorders, including depression. With all the recent (and warranted) attention given to epigenetic modifications in mature neurons, it is easy to forget that epigenetic mechanisms were initially described for their ability to promote differentiation and drive cell fate in embryonic and early postnatal development, including neurogenesis. Given the discovery of ongoing neurogenesis in the adult brain and the intriguing links among adult hippocampal neurogenesis, hippocampal function, and neuropsychiatric disorders, it is timely to complement the ongoing discussions on the role of epigenetics in mature neurons with a review on what is currently known about the role of epigenetics in adult hippocampal neurogenesis. The process of adult hippocampal neurogenesis is complex, with neural stem cells (NSCs) giving rise to fate-restricted progenitors and eventually mature dentate gyrus granule cells. Notably, neurogenesis occurs within an increasingly well-defined "neurogenic niche", where mature cellular elements like vasculature, astrocytes, and neurons release signals that can dynamically regulate neurogenesis. Here we review the evidence that key stages and aspects of adult neurogenesis are driven by epigenetic mechanisms. We discuss the intrinsic changes occurring within NSCs and their progeny that are critical for neurogenesis. We also discuss how extrinsic changes occurring in cellular components in the niche can result in altered neurogenesis. Finally we describe the potential relevance of epigenetics for understanding the relationship between hippocampal neurogenesis in neuropsychiatric disorders. We propose that a more thorough understanding of the molecular and genetic mechanisms that control the complex process of neurogenesis, including the proliferation and differentiation of NSCs, will lead to novel therapeutics for the treatment of neuropsychiatric disorders.
KW - Adult neurogenesis
KW - Chromatin
KW - Depression
KW - Epigenetics
KW - Learning and memory
KW - Neural stem cell
UR - http://www.scopus.com/inward/record.url?scp=77952887349&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952887349&partnerID=8YFLogxK
U2 - 10.1016/j.nbd.2010.01.008
DO - 10.1016/j.nbd.2010.01.008
M3 - Review article
C2 - 20114075
AN - SCOPUS:77952887349
SN - 0969-9961
VL - 39
SP - 73
EP - 84
JO - Neurobiology of Disease
JF - Neurobiology of Disease
IS - 1
ER -