ERBB receptors in cancer: signaling from the inside.

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ERBB receptor tyrosine kinases are activated by ligand-induced dimerization followed by activation and transphosphorylation of their intracellular kinase domains. A recent study by Bill and colleagues demonstrates that receptor transphosphorylation can be regulated from inside the cell by members of the cytohesin protein family. These data highlight a novel mechanism of amplification of ERBB receptor signaling output that may contribute to embryogenesis and cancer progression.

Original languageEnglish (US)
Number of pages1
JournalBreast cancer research : BCR
Issue number2
Publication statusPublished - Dec 1 2011


ASJC Scopus subject areas

  • Medicine(all)

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