ERBB receptors in cancer

signaling from the inside.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

ERBB receptor tyrosine kinases are activated by ligand-induced dimerization followed by activation and transphosphorylation of their intracellular kinase domains. A recent study by Bill and colleagues demonstrates that receptor transphosphorylation can be regulated from inside the cell by members of the cytohesin protein family. These data highlight a novel mechanism of amplification of ERBB receptor signaling output that may contribute to embryogenesis and cancer progression.

Original languageEnglish (US)
Number of pages1
JournalBreast cancer research : BCR
Volume13
Issue number2
StatePublished - Dec 1 2011

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Receptor Protein-Tyrosine Kinases
Dimerization
Embryonic Development
Phosphotransferases
Ligands
Neoplasms
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

ERBB receptors in cancer : signaling from the inside. / Arteaga, Carlos L.

In: Breast cancer research : BCR, Vol. 13, No. 2, 01.12.2011.

Research output: Contribution to journalArticle

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