Abstract
ERBB receptor tyrosine kinases are activated by ligand-induced dimerization followed by activation and transphosphorylation of their intracellular kinase domains. A recent study by Bill and colleagues demonstrates that receptor transphosphorylation can be regulated from inside the cell by members of the cytohesin protein family. These data highlight a novel mechanism of amplification of ERBB receptor signaling output that may contribute to embryogenesis and cancer progression.
Original language | English (US) |
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Pages (from-to) | 304 |
Number of pages | 1 |
Journal | Breast cancer research : BCR |
Volume | 13 |
Issue number | 2 |
DOIs | |
State | Published - 2011 |
ASJC Scopus subject areas
- Oncology
- Cancer Research