ERBB receptors in cancer: signaling from the inside.

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

ERBB receptor tyrosine kinases are activated by ligand-induced dimerization followed by activation and transphosphorylation of their intracellular kinase domains. A recent study by Bill and colleagues demonstrates that receptor transphosphorylation can be regulated from inside the cell by members of the cytohesin protein family. These data highlight a novel mechanism of amplification of ERBB receptor signaling output that may contribute to embryogenesis and cancer progression.

Original languageEnglish (US)
Pages (from-to)304
Number of pages1
JournalBreast cancer research : BCR
Volume13
Issue number2
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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