Erythrocyte adenosine triphosphate and 2,3 diphosphoglycerate after human renal transplantation: Dissociation from hypophosphataemia

C. G. Barcenas, P. Paez, K. Uyeda, P. C. Peters, A. R. Hull

Research output: Contribution to journalArticle

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Abstract

Erythrocyte 2,3 diphosphoglycerate (2,3 DPG) and adenosine triphosphate (ATP) were determined in normal individuals, uremic patients on chronic hemodialysis and patients who underwent renal transplantation, and correlated with plasma phosphate and arterial blood pH. Significant increases in the 2,3 DPG and ATP content were found in the uremic patients and these persisted after transplantation in spite of marked hypophosphatemia. No correlation was established with plasma phosphate for either of the compounds but 2,3 DPG had a significant correlation with arterial blood pH. Normal values for ATP and 2,3 DPG were observed in post transplant patients with normal hematological values. The high amounts of erythrocyte 2,3 DPG and ATP in the early post transplant period are independent of the circulating concentration of inorganic phosphate, and might represent the response of erythrocyte glycolysis to changing arterial blood pH.

Original languageEnglish (US)
Pages (from-to)413-422
Number of pages10
JournalClinical Science and Molecular Medicine
Volume52
Issue number4
StatePublished - 1977

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2,3-Diphosphoglycerate
Kidney Transplantation
Adenosine Triphosphate
Erythrocytes
Phosphates
Reference Values
Hypophosphatemia
Transplants
Glycolysis
Renal Dialysis
Transplantation

ASJC Scopus subject areas

  • Medicine(all)

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Erythrocyte adenosine triphosphate and 2,3 diphosphoglycerate after human renal transplantation : Dissociation from hypophosphataemia. / Barcenas, C. G.; Paez, P.; Uyeda, K.; Peters, P. C.; Hull, A. R.

In: Clinical Science and Molecular Medicine, Vol. 52, No. 4, 1977, p. 413-422.

Research output: Contribution to journalArticle

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